CREB3L2

Summary: This gene encodes a member of the oasis bZIP transcription factor family. Members of this family can dimerize but form homodimers only. The encoded protein is a transcriptional activator. Translocations between this gene on chromosome 7 and the gene fused in sarcoma on chromosome 16 can be found in some tumors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NamecAMP responsive element binding protein 3 like 2
OMIM IDMIM:608834
Ensembl IDEnsembl:ENSG00000182158
HGNC IDHGNC:HGNC:23720
PHARMGKB IDPA134914841
Map Location7q33

GO terms in CREB3L2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF ISM GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IEA GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF IBA GO:0035497 cAMP response element binding
MF IMP GO:0035497 cAMP response element binding
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Gene expression in normal tissue: CREB3L2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 18

Gene-drug pathway distribution

undefined6p53 pathway1

Pathways in CREB3L2


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Database
Pathway ID
Pathway Des.
reactome R-HSA-381119 Unfolded Protein Response (UPR)
reactome R-HSA-392499 Metabolism of proteins
reactome R-HSA-8874211 CREB3 factors activate genes
kegg hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
kegg hsa04024 cAMP signaling pathway - Homo sapiens (human)
kegg hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD451 Serdemetan 2
iGMDRD187 BRD9876 3
iGMDRD434 BMS-536924 2
iGMDRD679 Bistramide A 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CREB3L2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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