RIPK1


Summary: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
receptor interacting serine/threonine kinase 1MIM:603453Ensembl:ENSG00000137275HGNC:HGNC:10019PA343946p25.2

GO terms in RIPK1


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0000165MAPK cascade
BPIMPGO:0001934positive regulation of protein phosphorylation
BPTASGO:0002756MyD88-independent toll-like receptor signaling pathway
BPIMPGO:0006915apoptotic process
BPTASGO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process
BPTASGO:0007249I-kappaB kinase/NF-kappaB signaling
BPIBAGO:0007257activation of JUN kinase activity
BPTASGO:0007257activation of JUN kinase activity
BPTASGO:0010803regulation of tumor necrosis factor-mediated signaling pathway
BPIMPGO:0010940positive regulation of necrotic cell death
BPIEAGO:0016032viral process
BPTASGO:0016579protein deubiquitination
BPIDAGO:0032757positive regulation of interleukin-8 production
BPIDAGO:0032760positive regulation of tumor necrosis factor production
BPICGO:0033209tumor necrosis factor-mediated signaling pathway
BPTASGO:0033209tumor necrosis factor-mediated signaling pathway
BPTASGO:0034138toll-like receptor 3 signaling pathway
BPIMPGO:0034612response to tumor necrosis factor
BPTASGO:0035666TRIF-dependent toll-like receptor signaling pathway
BPIDAGO:0036289peptidyl-serine autophosphorylation
BPIDAGO:0043065positive regulation of apoptotic process
BPIMPGO:0043065positive regulation of apoptotic process
BPIMPGO:0043068positive regulation of programmed cell death
BPIDAGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIEPGO:0043123positive regulation of I-kappaB kinase/NF-kappaB signaling
BPIMPGO:0043124negative regulation of I-kappaB kinase/NF-kappaB signaling
BPIDAGO:0044257cellular protein catabolic process
BPIMPGO:0045651positive regulation of macrophage differentiation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046330positive regulation of JNK cascade
BPIDAGO:0046777protein autophosphorylation
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIDAGO:0051260protein homooligomerization
BPIMPGO:0051291protein heterooligomerization
BPIMPGO:0060545positive regulation of necroptotic process
BPISSGO:0070231T cell apoptotic process
BPIMPGO:0070266necroptotic process
BPTASGO:0070266necroptotic process
BPIMPGO:0070926regulation of ATP:ADP antiporter activity
BPIDAGO:0071356cellular response to tumor necrosis factor
BPIEAGO:0071363cellular response to growth factor stimulus
BPTASGO:0071550death-inducing signaling complex assembly
BPTASGO:0097190apoptotic signaling pathway
BPIDAGO:0097191extrinsic apoptotic signaling pathway
BPIMPGO:0097191extrinsic apoptotic signaling pathway
BPIMPGO:0097343ripoptosome assembly
BPIMPGO:0097527necroptotic signaling pathway
BPISSGO:0097527necroptotic signaling pathway
BPTASGO:1902041regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPTASGO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
BPIMPGO:1905206positive regulation of hydrogen peroxide-induced cell death
BPIMPGO:1990000amyloid fibril formation
BPTASGO:2000379positive regulation of reactive oxygen species metabolic process
BPIMPGO:2001237negative regulation of extrinsic apoptotic signaling pathway
BPIMPGO:2001238positive regulation of extrinsic apoptotic signaling pathway
BPIEAGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
CCIDAGO:0005739mitochondrion
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCTASGO:0010008endosome membrane
CCIDAGO:0031264death-inducing signaling complex
CCIDAGO:0043235receptor complex
CCIEAGO:0045121membrane raft
CCIDAGO:0097342ripoptosome
MFIDAGO:0004672protein kinase activity
MFIMPGO:0004672protein kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004706JUN kinase kinase kinase activity
MFIPIGO:0005123death receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIPIGO:0042802identical protein binding
MFIDAGO:0044877protein-containing complex binding
MFIPIGO:0070513death domain binding

Gene expression in normal tissue: RIPK1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RIPK1


DatabasePathway IDPathway Des.
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2036TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathwaysWP231TNF alpha Signaling Pathway
wikipathwaysWP2512Integrated Lung Cancer Pathway
wikipathwaysWP2513Nanoparticle triggered regulated necrosis
wikipathwaysWP254Apoptosis
wikipathwaysWP3639Apoptotic Signaling Pathway
wikipathwaysWP384Apoptosis Modulation by HSP70
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP400p38 MAPK Signaling Pathway
wikipathwaysWP75Toll-like Receptor Signaling Pathway
pidcaspase_pathwayCaspase Cascade in Apoptosis
pidceramide_pathwayCeramide signaling pathway
pidfaspathwayFAS (CD95) signaling pathway
pidhivnefpathwayHIV-1 Nef: Negative effector of Fas and TNF-alpha
pidp38alphabetapathwayRegulation of p38-alpha and p38-beta
pidtnfpathwayTNF receptor signaling pathway
pidtrail_pathwayTRAIL signaling pathway
netpathPathway_EGFR1EGFR1
netpathPathway_TNFalphaTNFalpha
netpathPathway_TWEAKTWEAK
kegghsa04064NF-kappa B signaling pathway - Homo sapiens (human)
kegghsa04210Apoptosis - Homo sapiens (human)
kegghsa04217Necroptosis - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04623Cytosolic DNA-sensing pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
biocartaceramidepathwayceramide signaling pathway
biocartadeathpathwayinduction of apoptosis through dr3 and dr4/5 death receptors
biocartahivnefpathwayhiv-1 nef: negative effector of fas and tnf
biocartakeratinocytepathwaykeratinocyte differentiation
biocartanfkbpathwaynf-kb signaling pathway
biocartasoddpathwaysodd/tnfr1 signaling pathway
biocartastresspathwaytnf/stress related signaling
biocartatnfr1pathwaytnfr1 signaling pathway
biocartatnfr2pathwaytnfr2 signaling pathway
reactomeR-HSA-109581Apoptosis
reactomeR-HSA-140534via Death Receptors in the presence of ligand
reactomeR-HSA-1606322ZBP1(DAI) mediated induction of type I IFNs
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-168927TICAM1, RIP1-mediated IKK complex recruitment
reactomeR-HSA-168928DDX58/IFIH1-mediated induction of interferon-alpha/beta
reactomeR-HSA-1810476RIP-mediated NFkB activation via ZBP1
reactomeR-HSA-1834949Cytosolic sensors of pathogen-associated DNA
reactomeR-HSA-2562578TRIF-mediated programmed cell death
reactomeR-HSA-2672351Stimuli-sensing channels
reactomeR-HSA-3295583TRP channels
reactomeR-HSA-3371378Regulation by c-FLIP
reactomeR-HSA-382551Transport of small molecules
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-5213460RIPK1-mediated regulated necrosis
reactomeR-HSA-5218859Regulated Necrosis
reactomeR-HSA-5218900CASP8 activity is inhibited
reactomeR-HSA-5357769Caspase activation via extrinsic apoptotic signalling pathway
reactomeR-HSA-5357786TNFR1-induced proapoptotic signaling
reactomeR-HSA-5357801Programmed Cell Death
reactomeR-HSA-5357905Regulation of TNFR1 signaling
reactomeR-HSA-5357956TNFR1-induced NFkappaB signaling pathway
reactomeR-HSA-5675482Regulation of necroptotic cell death
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-5689896Ovarian tumor domain proteases
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-69416Dimerization of procaspase-8
reactomeR-HSA-73887Death Receptor Signalling
reactomeR-HSA-75893TNF signaling
reactomeR-HSA-9013957TLR3-mediated TICAM1-dependent programmed cell death
reactomeR-HSA-933543NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
reactomeR-HSA-937041IKK complex recruitment mediated by RIP1
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-983712Ion channel transport

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD329Merck603
iGMDRD57Chloropentafluorobenzene3
iGMDRD202Curcumin3
iGMDRD446LY 21832401
iGMDRD871BRD63683
iGMDRD77Itraconazole3
iGMDRD434BMS-5369243

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RIPK1

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