RIPK1
Summary: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| receptor interacting serine/threonine kinase 1 | MIM:603453 | Ensembl:ENSG00000137275 | HGNC:HGNC:10019 | PA34394 | 6p25.2 |
GO terms in RIPK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IMP | GO:0001934 | positive regulation of protein phosphorylation |
| BP | TAS | GO:0002756 | MyD88-independent toll-like receptor signaling pathway |
| BP | IMP | GO:0006915 | apoptotic process |
| BP | TAS | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | TAS | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IBA | GO:0007257 | activation of JUN kinase activity |
| BP | TAS | GO:0007257 | activation of JUN kinase activity |
| BP | TAS | GO:0010803 | regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IMP | GO:0010940 | positive regulation of necrotic cell death |
| BP | IEA | GO:0016032 | viral process |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0032757 | positive regulation of interleukin-8 production |
| BP | IDA | GO:0032760 | positive regulation of tumor necrosis factor production |
| BP | IC | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0033209 | tumor necrosis factor-mediated signaling pathway |
| BP | TAS | GO:0034138 | toll-like receptor 3 signaling pathway |
| BP | IMP | GO:0034612 | response to tumor necrosis factor |
| BP | TAS | GO:0035666 | TRIF-dependent toll-like receptor signaling pathway |
| BP | IDA | GO:0036289 | peptidyl-serine autophosphorylation |
| BP | IDA | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043068 | positive regulation of programmed cell death |
| BP | IDA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IMP | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0044257 | cellular protein catabolic process |
| BP | IMP | GO:0045651 | positive regulation of macrophage differentiation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046330 | positive regulation of JNK cascade |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0051260 | protein homooligomerization |
| BP | IMP | GO:0051291 | protein heterooligomerization |
| BP | IMP | GO:0060545 | positive regulation of necroptotic process |
| BP | ISS | GO:0070231 | T cell apoptotic process |
| BP | IMP | GO:0070266 | necroptotic process |
| BP | TAS | GO:0070266 | necroptotic process |
| BP | IMP | GO:0070926 | regulation of ATP:ADP antiporter activity |
| BP | IDA | GO:0071356 | cellular response to tumor necrosis factor |
| BP | IEA | GO:0071363 | cellular response to growth factor stimulus |
| BP | TAS | GO:0071550 | death-inducing signaling complex assembly |
| BP | TAS | GO:0097190 | apoptotic signaling pathway |
| BP | IDA | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IMP | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | IMP | GO:0097343 | ripoptosome assembly |
| BP | IMP | GO:0097527 | necroptotic signaling pathway |
| BP | ISS | GO:0097527 | necroptotic signaling pathway |
| BP | TAS | GO:1902041 | regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | TAS | GO:1902042 | negative regulation of extrinsic apoptotic signaling pathway via death domain receptors |
| BP | IMP | GO:1905206 | positive regulation of hydrogen peroxide-induced cell death |
| BP | IMP | GO:1990000 | amyloid fibril formation |
| BP | TAS | GO:2000379 | positive regulation of reactive oxygen species metabolic process |
| BP | IMP | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| BP | IMP | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway |
| BP | IEA | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0010008 | endosome membrane |
| CC | IDA | GO:0031264 | death-inducing signaling complex |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IEA | GO:0045121 | membrane raft |
| CC | IDA | GO:0097342 | ripoptosome |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IMP | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004706 | JUN kinase kinase kinase activity |
| MF | IPI | GO:0005123 | death receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0044877 | protein-containing complex binding |
| MF | IPI | GO:0070513 | death domain binding |
Gene expression in normal tissue: RIPK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RIPK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2036 | TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
| wikipathways | WP2513 | Nanoparticle triggered regulated necrosis |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP384 | Apoptosis Modulation by HSP70 |
| wikipathways | WP3865 | RIG-I-like Receptor Signaling |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | ceramide_pathway | Ceramide signaling pathway |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | p38alphabetapathway | Regulation of p38-alpha and p38-beta |
| pid | tnfpathway | TNF receptor signaling pathway |
| pid | trail_pathway | TRAIL signaling pathway |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TNFalpha | TNFalpha |
| netpath | Pathway_TWEAK | TWEAK |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04217 | Necroptosis - Homo sapiens (human) |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04621 | NOD-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04622 | RIG-I-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04623 | Cytosolic DNA-sensing pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| biocarta | ceramidepathway | ceramide signaling pathway |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | keratinocytepathway | keratinocyte differentiation |
| biocarta | nfkbpathway | nf-kb signaling pathway |
| biocarta | soddpathway | sodd/tnfr1 signaling pathway |
| biocarta | stresspathway | tnf/stress related signaling |
| biocarta | tnfr1pathway | tnfr1 signaling pathway |
| biocarta | tnfr2pathway | tnfr2 signaling pathway |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-140534 | via Death Receptors in the presence of ligand |
| reactome | R-HSA-1606322 | ZBP1(DAI) mediated induction of type I IFNs |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-166016 | Toll Like Receptor 4 (TLR4) Cascade |
| reactome | R-HSA-166166 | MyD88-independent TLR4 cascade |
| reactome | R-HSA-168164 | Toll Like Receptor 3 (TLR3) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-168927 | TICAM1, RIP1-mediated IKK complex recruitment |
| reactome | R-HSA-168928 | DDX58/IFIH1-mediated induction of interferon-alpha/beta |
| reactome | R-HSA-1810476 | RIP-mediated NFkB activation via ZBP1 |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-2562578 | TRIF-mediated programmed cell death |
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-3295583 | TRP channels |
| reactome | R-HSA-3371378 | Regulation by c-FLIP |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5213460 | RIPK1-mediated regulated necrosis |
| reactome | R-HSA-5218859 | Regulated Necrosis |
| reactome | R-HSA-5218900 | CASP8 activity is inhibited |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357786 | TNFR1-induced proapoptotic signaling |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5357905 | Regulation of TNFR1 signaling |
| reactome | R-HSA-5357956 | TNFR1-induced NFkappaB signaling pathway |
| reactome | R-HSA-5675482 | Regulation of necroptotic cell death |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-5689896 | Ovarian tumor domain proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-69416 | Dimerization of procaspase-8 |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75893 | TNF signaling |
| reactome | R-HSA-9013957 | TLR3-mediated TICAM1-dependent programmed cell death |
| reactome | R-HSA-933543 | NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 |
| reactome | R-HSA-937041 | IKK complex recruitment mediated by RIP1 |
| reactome | R-HSA-937061 | TRIF(TICAM1)-mediated TLR4 signaling |
| reactome | R-HSA-983712 | Ion channel transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 3 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD434 | BMS-536924 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RIPK1
CLASSFICATION
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