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RIPK1

Summary: This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Namereceptor interacting serine/threonine kinase 1 OMIM IDMIM:603453 Ensembl IDEnsembl:ENSG00000137275 HGNC IDHGNC:HGNC:10019 PHARMGKB IDPA34394 Map Location6p25.2

Gene Categories:

DRUGGABLE GENOME TRANSPORTER SERINE THREONINE KINASE PROTEASE KINASE

GO terms in RIPK1

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0000165	MAPK cascade
BP	IMP	GO:0001934	positive regulation of protein phosphorylation
BP	TAS	GO:0002756	MyD88-independent toll-like receptor signaling pathway
BP	IMP	GO:0006915	apoptotic process
BP	TAS	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process
BP	TAS	GO:0007249	I-kappaB kinase/NF-kappaB signaling

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Gene expression in normal tissue: RIPK1

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RIPK1

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Database	Pathway ID	Pathway Des.
wikipathways	WP1449	Regulation of toll-like receptor signaling pathway
wikipathways	WP1772	Apoptosis Modulation and Signaling
wikipathways	WP2036	TNF related weak inducer of apoptosis (TWEAK) Signaling Pathway
wikipathways	WP231	TNF alpha Signaling Pathway
wikipathways	WP2512	Integrated Lung Cancer Pathway
wikipathways	WP2513	Nanoparticle triggered regulated necrosis

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD329	Merck60	3
iGMDRD57	Chloropentafluorobenzene	3
iGMDRD202	Curcumin	3
iGMDRD446	LY 2183240	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RIPK1

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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