PRKD2
Summary: The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| protein kinase D2 | MIM:607074 | Ensembl:ENSG00000105287 | HGNC:HGNC:17293 | PA134903505 | 19q13.32 |
GO terms in PRKD2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IMP | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IEA | GO:0004697 | protein kinase C activity |
| MF | IPI | GO:0005080 | protein kinase C binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| BP | IEA | GO:0001525 | angiogenesis |
| BP | IGI | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IMP | GO:0001938 | positive regulation of endothelial cell proliferation |
| BP | IEA | GO:0002250 | adaptive immune response |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | NAS | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | IMP | GO:0008219 | cell death |
| BP | IMP | GO:0010595 | positive regulation of endothelial cell migration |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IMP | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | TAS | GO:0030148 | sphingolipid biosynthetic process |
| BP | IMP | GO:0030949 | positive regulation of vascular endothelial growth factor receptor signaling pathway |
| BP | ISS | GO:0032743 | positive regulation of interleukin-2 production |
| BP | IMP | GO:0032757 | positive regulation of interleukin-8 production |
| BP | IGI | GO:0032793 | positive regulation of CREB transcription factor activity |
| BP | IGI | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IMP | GO:0035556 | intracellular signal transduction |
| BP | IGI | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IMP | GO:0035924 | cellular response to vascular endothelial growth factor stimulus |
| BP | IGI | GO:0038033 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway |
| BP | IMP | GO:0038033 | positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway |
| BP | IGI | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IMP | GO:0043536 | positive regulation of blood vessel endothelial cell migration |
| BP | IMP | GO:0045743 | positive regulation of fibroblast growth factor receptor signaling pathway |
| BP | IGI | GO:0045766 | positive regulation of angiogenesis |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | IMP | GO:0045785 | positive regulation of cell adhesion |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0046777 | protein autophosphorylation |
| BP | IMP | GO:0048010 | vascular endothelial growth factor receptor signaling pathway |
| BP | IDA | GO:0050852 | T cell receptor signaling pathway |
| BP | ISS | GO:0050862 | positive regulation of T cell receptor signaling pathway |
| BP | IMP | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | TAS | GO:0061154 | endothelial tube morphogenesis |
| BP | ISS | GO:0070374 | positive regulation of ERK1 and ERK2 cascade |
| BP | IBA | GO:0089700 | protein kinase D signaling |
| BP | IGI | GO:0089700 | protein kinase D signaling |
| BP | IGI | GO:1901727 | positive regulation of histone deacetylase activity |
| BP | IMP | GO:1902533 | positive regulation of intracellular signal transduction |
| BP | ISS | GO:2000573 | positive regulation of DNA biosynthetic process |
| BP | IMP | GO:2001028 | positive regulation of endothelial cell chemotaxis |
Gene expression in normal tissue: PRKD2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PRKD2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_TCR | TCR |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04925 | Aldosterone synthesis and secretion - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1660661 | Sphingolipid de novo biosynthesis |
| reactome | R-HSA-428157 | Sphingolipid metabolism |
| reactome | R-HSA-556833 | Metabolism of lipids |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD366 | PI-103 | 2 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD871 | BRD6368 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PRKD2
CLASSFICATION
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