PRKD2


Summary: The protein encoded by this gene belongs to the protein kinase D (PKD) family of serine/threonine protein kinases. This kinase can be activated by phorbol esters as well as by gastrin via the cholecystokinin B receptor (CCKBR) in gastric cancer cells. It can bind to diacylglycerol (DAG) in the trans-Golgi network (TGN) and may regulate basolateral membrane protein exit from TGN. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
protein kinase D2MIM:607074Ensembl:ENSG00000105287HGNC:HGNC:17293PA13490350519q13.32

GO terms in PRKD2


Term TypeEvidence TypeGO Term IDGO Des.
MFIDAGO:0004672protein kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIMPGO:0004674protein serine/threonine kinase activity
MFNASGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIEAGO:0004697protein kinase C activity
MFIPIGO:0005080protein kinase C binding
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIEAGO:0046872metal ion binding
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005737cytoplasm
CCIEAGO:0005794Golgi apparatus
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIEAGO:0005886plasma membrane
BPIEAGO:0001525angiogenesis
BPIGIGO:0001938positive regulation of endothelial cell proliferation
BPIMPGO:0001938positive regulation of endothelial cell proliferation
BPIEAGO:0002250adaptive immune response
BPIDAGO:0006468protein phosphorylation
BPNASGO:0006468protein phosphorylation
BPIEAGO:0007155cell adhesion
BPIMPGO:0008219cell death
BPIMPGO:0010595positive regulation of endothelial cell migration
BPIDAGO:0018105peptidyl-serine phosphorylation
BPIMPGO:0018105peptidyl-serine phosphorylation
BPIMPGO:0018107peptidyl-threonine phosphorylation
BPTASGO:0030148sphingolipid biosynthetic process
BPIMPGO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathway
BPISSGO:0032743positive regulation of interleukin-2 production
BPIMPGO:0032757positive regulation of interleukin-8 production
BPIGIGO:0032793positive regulation of CREB transcription factor activity
BPIGIGO:0033138positive regulation of peptidyl-serine phosphorylation
BPIMPGO:0035556intracellular signal transduction
BPIGIGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIMPGO:0035924cellular response to vascular endothelial growth factor stimulus
BPIGIGO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
BPIMPGO:0038033positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway
BPIGIGO:0043536positive regulation of blood vessel endothelial cell migration
BPIMPGO:0043536positive regulation of blood vessel endothelial cell migration
BPIMPGO:0045743positive regulation of fibroblast growth factor receptor signaling pathway
BPIGIGO:0045766positive regulation of angiogenesis
BPIMPGO:0045766positive regulation of angiogenesis
BPIMPGO:0045785positive regulation of cell adhesion
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0046777protein autophosphorylation
BPTASGO:0046777protein autophosphorylation
BPIMPGO:0048010vascular endothelial growth factor receptor signaling pathway
BPIDAGO:0050852T cell receptor signaling pathway
BPISSGO:0050862positive regulation of T cell receptor signaling pathway
BPIMPGO:0051091positive regulation of DNA-binding transcription factor activity
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPTASGO:0061154endothelial tube morphogenesis
BPISSGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIBAGO:0089700protein kinase D signaling
BPIGIGO:0089700protein kinase D signaling
BPIGIGO:1901727positive regulation of histone deacetylase activity
BPIMPGO:1902533positive regulation of intracellular signal transduction
BPISSGO:2000573positive regulation of DNA biosynthetic process
BPIMPGO:2001028positive regulation of endothelial cell chemotaxis

Gene expression in normal tissue: PRKD2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PRKD2


DatabasePathway IDPathway Des.
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
netpathPathway_GastrinGastrin
netpathPathway_TCRTCR
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04925Aldosterone synthesis and secretion - Homo sapiens (human)
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1660661Sphingolipid de novo biosynthesis
reactomeR-HSA-428157Sphingolipid metabolism
reactomeR-HSA-556833Metabolism of lipids

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD434BMS-5369243
iGMDRD116CD4373
iGMDRD289Parthenolide1
iGMDRD705Nakiterpiosin3
iGMDRD945ML2146
iGMDRD297Austocystin D3
iGMDRD366PI-1032
iGMDRD329Merck606
iGMDRD414MST-3125
iGMDRD871BRD63683

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PRKD2

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