FSTL3


Summary: Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
follistatin like 3MIM:605343Ensembl:ENSG00000070404HGNC:HGNC:3973PA2839019p13.3

Gene Categories:

DRUGGABLE GENOME

GO terms in FSTL3


Term TypeEvidence TypeGO Term IDGO Des.
MFIPIGO:0001968fibronectin binding
MFIPIGO:0005515protein binding
MFIPIGO:0048185activin binding
CCTASGO:0005576extracellular region
CCIDAGO:0005615extracellular space
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005788endoplasmic reticulum lumen
CCIEAGO:0005794Golgi apparatus
CCIEAGO:0030141secretory granule
CCIEAGO:0044306neuron projection terminus
BPIEAGO:0001503ossification
BPIEAGO:0001822kidney development
BPIDAGO:0002244hematopoietic progenitor cell differentiation
BPIEAGO:0006351transcription, DNA-templated
BPIDAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0007283spermatogenesis
BPIEAGO:0008584male gonad development
BPIDAGO:0022409positive regulation of cell-cell adhesion
BPIEAGO:0030324lung development
BPIEAGO:0030325adrenal gland development
BPIDAGO:0030514negative regulation of BMP signaling pathway
BPIDAGO:0032926negative regulation of activin receptor signaling pathway
BPTASGO:0043687post-translational protein modification
BPTASGO:0044267cellular protein metabolic process
BPIDAGO:0045671negative regulation of osteoclast differentiation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIEAGO:0071248cellular response to metal ion
BPIDAGO:0090101negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway

Gene expression in normal tissue: FSTL3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FSTL3


DatabasePathway IDPathway Des.
reactomeR-HSA-1502540Signaling by Activin
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-2473224Antagonism of Activin by Follistatin
reactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-8957275Post-translational protein phosphorylation
reactomeR-HSA-9006936Signaling by TGF-beta family members

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD289Parthenolide1
iGMDRD105Triptolide3
iGMDRD318PAC-11
iGMDRD945ML2146

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FSTL3

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