FSTL3
Summary: Follistatin-like 3 is a secreted glycoprotein of the follistatin-module-protein family. It may have a role in leukemogenesis. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| follistatin like 3 | MIM:605343 | Ensembl:ENSG00000070404 | HGNC:HGNC:3973 | PA28390 | 19p13.3 |
Gene Categories:
DRUGGABLE GENOMEGO terms in FSTL3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0001968 | fibronectin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0048185 | activin binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005615 | extracellular space |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | IEA | GO:0005794 | Golgi apparatus |
| CC | IEA | GO:0030141 | secretory granule |
| CC | IEA | GO:0044306 | neuron projection terminus |
| BP | IEA | GO:0001503 | ossification |
| BP | IEA | GO:0001822 | kidney development |
| BP | IDA | GO:0002244 | hematopoietic progenitor cell differentiation |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IDA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0008584 | male gonad development |
| BP | IDA | GO:0022409 | positive regulation of cell-cell adhesion |
| BP | IEA | GO:0030324 | lung development |
| BP | IEA | GO:0030325 | adrenal gland development |
| BP | IDA | GO:0030514 | negative regulation of BMP signaling pathway |
| BP | IDA | GO:0032926 | negative regulation of activin receptor signaling pathway |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IDA | GO:0045671 | negative regulation of osteoclast differentiation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0071248 | cellular response to metal ion |
| BP | IDA | GO:0090101 | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
Gene expression in normal tissue: FSTL3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FSTL3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1502540 | Signaling by Activin |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2473224 | Antagonism of Activin by Follistatin |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
| reactome | R-HSA-9006936 | Signaling by TGF-beta family members |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD945 | ML214 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FSTL3
CLASSFICATION
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