HSPA1A


Summary: This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
heat shock protein family A (Hsp70) member 1AMIM:140550Ensembl:ENSG00000204389HGNC:HGNC:5232PA294986p21.33

GO terms in HSPA1A


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0001618virus receptor activity
MFIDAGO:0001664G-protein coupled receptor binding
MFIDAGO:0003714transcription corepressor activity
MFHDAGO:0003723RNA binding
MFIPIGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIBAGO:0005524ATP binding
MFIDAGO:0005524ATP binding
MFIBAGO:0016887ATPase activity
MFIDAGO:0016887ATPase activity
MFIPIGO:0019899enzyme binding
MFIBAGO:0031072heat shock protein binding
MFIPIGO:0031072heat shock protein binding
MFIPIGO:0031249denatured protein binding
MFIBAGO:0031625ubiquitin protein ligase binding
MFIPIGO:0031625ubiquitin protein ligase binding
MFIBAGO:0042623ATPase activity, coupled
MFIDAGO:0042623ATPase activity, coupled
MFTASGO:0042623ATPase activity, coupled
MFIPIGO:0042826histone deacetylase binding
MFIBAGO:0044183protein binding involved in protein folding
MFIDAGO:0044183protein binding involved in protein folding
MFHDAGO:0045296cadherin binding
MFIPIGO:0047485protein N-terminus binding
MFIBAGO:0051082unfolded protein binding
MFIDAGO:0051082unfolded protein binding
MFNASGO:0051082unfolded protein binding
MFTASGO:0051082unfolded protein binding
MFIBAGO:0051787misfolded protein binding
MFIPIGO:0055131C3HC4-type RING finger domain binding
MFIPIGO:0097718disordered domain specific binding
CCIDAGO:0000151ubiquitin ligase complex
CCTASGO:0005576extracellular region
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
CCTASGO:0005737cytoplasm
CCTASGO:0005739mitochondrion
CCTASGO:0005783endoplasmic reticulum
CCIDAGO:0005813centrosome
CCIDAGO:0005814centriole
CCIBAGO:0005829cytosol
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCHDAGO:0005925focal adhesion
CCIBAGO:0008180COP9 signalosome
CCIDAGO:0008180COP9 signalosome
CCIDAGO:0016234inclusion body
CCIDAGO:0016235aggresome
CCIDAGO:0016607nuclear speck
CCHDAGO:0031982vesicle
CCIDAGO:0032991protein-containing complex
CCIDAGO:0048471perinuclear region of cytoplasm
CCHDAGO:0070062extracellular exosome
CCHDAGO:0072562blood microparticle
CCTASGO:1904813ficolin-1-rich granule lumen
CCIDAGO:1990904ribonucleoprotein complex
BPIDAGO:0006402mRNA catabolic process
BPIBAGO:0006986response to unfolded protein
BPIDAGO:0006986response to unfolded protein
BPIMPGO:0008285negative regulation of cell proliferation
BPIMPGO:0010628positive regulation of gene expression
BPIMPGO:0010941regulation of cell death
BPIMPGO:0030308negative regulation of cell growth
BPIMPGO:0030512negative regulation of transforming growth factor beta receptor signaling pathway
BPIDAGO:0031396regulation of protein ubiquitination
BPIDAGO:0031397negative regulation of protein ubiquitination
BPIBAGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIDAGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPIMPGO:0032757positive regulation of interleukin-8 production
BPIDAGO:0033120positive regulation of RNA splicing
BPTASGO:0034599cellular response to oxidative stress
BPIBAGO:0034605cellular response to heat
BPIDAGO:0034605cellular response to heat
BPIBAGO:0034620cellular response to unfolded protein
BPIMPGO:0034620cellular response to unfolded protein
BPIBAGO:0042026protein refolding
BPIDAGO:0042026protein refolding
BPIMPGO:0042026protein refolding
BPIMPGO:0043066negative regulation of apoptotic process
BPTASGO:0043066negative regulation of apoptotic process
BPTASGO:0043312neutrophil degranulation
BPTASGO:0043488regulation of mRNA stability
BPIMPGO:0045648positive regulation of erythrocyte differentiation
BPIDAGO:0046034ATP metabolic process
BPIEAGO:0046718viral entry into host cell
BPIDAGO:0050821protein stabilization
BPIMPGO:0050821protein stabilization
BPTASGO:0050821protein stabilization
BPIBAGO:0051085chaperone cofactor-dependent protein refolding
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIDAGO:0051131chaperone-mediated protein complex assembly
BPIMPGO:0060548negative regulation of cell death
BPIMPGO:0070370cellular heat acclimation
BPIMPGO:0070434positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
BPIMPGO:0090063positive regulation of microtubule nucleation
BPIDAGO:0090084negative regulation of inclusion body assembly
BPIDAGO:0097201negative regulation of transcription from RNA polymerase II promoter in response to stress
BPTASGO:1900034regulation of cellular response to heat
BPIDAGO:1901029negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
BPIBAGO:1901673regulation of mitotic spindle assembly
BPIMPGO:1901673regulation of mitotic spindle assembly
BPIDAGO:1902236negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
BPIDAGO:1902380positive regulation of endoribonuclease activity
BPIMPGO:1903265positive regulation of tumor necrosis factor-mediated signaling pathway
BPIMPGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

Gene expression in normal tissue: HSPA1A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in HSPA1A


DatabasePathway IDPathway Des.
reactomeR-HSA-1643685Disease
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168255Influenza Life Cycle
reactomeR-HSA-168256Immune System
reactomeR-HSA-168274Export of Viral Ribonucleoproteins from Nucleus
reactomeR-HSA-168330Viral RNP Complexes in the Host Cell Nucleus
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-3371453Regulation of HSF1-mediated heat shock response
reactomeR-HSA-3371497HSP90 chaperone cycle for steroid hormone receptors (SHR)
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-3371568Attenuation phase
reactomeR-HSA-3371571HSF1-dependent transactivation
reactomeR-HSA-450408AUF1 (hnRNP D0) binds and destabilizes mRNA
reactomeR-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elements
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-6798695Neutrophil degranulation
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-8953897Cellular responses to external stimuli
biocartaarfpathwaytumor suppressor arf inhibits ribosomal biogenesis
biocartap53hypoxiapathwayhypoxia and p53 in the cardiovascular system
biocartapparapathwaymechanism of gene regulation by peroxisome proliferators via ppara
biocartatidpathwaychaperones modulate interferon signaling pathway
pidfoxm1pathwayFOXM1 transcription factor network
pidp53downstreampathwayDirect p53 effectors
kegghsa03040Spliceosome - Homo sapiens (human)
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04141Protein processing in endoplasmic reticulum - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04213Longevity regulating pathway - multiple species - Homo sapiens (human)
kegghsa04612Antigen processing and presentation - Homo sapiens (human)
kegghsa04915Estrogen signaling pathway - Homo sapiens (human)
kegghsa05020Prion diseases - Homo sapiens (human)
kegghsa05134Legionellosis - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05162Measles - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
netpathPathway_AndrogenReceptorAndrogenReceptor
wikipathwaysWP1772Apoptosis Modulation and Signaling
wikipathwaysWP2359Parkin-Ubiquitin Proteasomal System pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP2884NRF2 pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP384Apoptosis Modulation by HSP70
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD318PAC-11
iGMDRD945ML2146
iGMDRD105Triptolide3
iGMDRD289Parthenolide1
iGMDRD577BIX012942
iGMDRD146Elesclomol1
iGMDRD210AC556493

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HSPA1A

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