HSPA1A
Summary: This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| heat shock protein family A (Hsp70) member 1A | MIM:140550 | Ensembl:ENSG00000204389 | HGNC:HGNC:5232 | PA29498 | 6p21.33 |
GO terms in HSPA1A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IDA | GO:0001664 | G-protein coupled receptor binding |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005524 | ATP binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IBA | GO:0016887 | ATPase activity |
| MF | IDA | GO:0016887 | ATPase activity |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IBA | GO:0031072 | heat shock protein binding |
| MF | IPI | GO:0031072 | heat shock protein binding |
| MF | IPI | GO:0031249 | denatured protein binding |
| MF | IBA | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IBA | GO:0042623 | ATPase activity, coupled |
| MF | IDA | GO:0042623 | ATPase activity, coupled |
| MF | TAS | GO:0042623 | ATPase activity, coupled |
| MF | IPI | GO:0042826 | histone deacetylase binding |
| MF | IBA | GO:0044183 | protein binding involved in protein folding |
| MF | IDA | GO:0044183 | protein binding involved in protein folding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IPI | GO:0047485 | protein N-terminus binding |
| MF | IBA | GO:0051082 | unfolded protein binding |
| MF | IDA | GO:0051082 | unfolded protein binding |
| MF | NAS | GO:0051082 | unfolded protein binding |
| MF | TAS | GO:0051082 | unfolded protein binding |
| MF | IBA | GO:0051787 | misfolded protein binding |
| MF | IPI | GO:0055131 | C3HC4-type RING finger domain binding |
| MF | IPI | GO:0097718 | disordered domain specific binding |
| CC | IDA | GO:0000151 | ubiquitin ligase complex |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005783 | endoplasmic reticulum |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005814 | centriole |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IBA | GO:0008180 | COP9 signalosome |
| CC | IDA | GO:0008180 | COP9 signalosome |
| CC | IDA | GO:0016234 | inclusion body |
| CC | IDA | GO:0016235 | aggresome |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | HDA | GO:0031982 | vesicle |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | HDA | GO:0072562 | blood microparticle |
| CC | TAS | GO:1904813 | ficolin-1-rich granule lumen |
| CC | IDA | GO:1990904 | ribonucleoprotein complex |
| BP | IDA | GO:0006402 | mRNA catabolic process |
| BP | IBA | GO:0006986 | response to unfolded protein |
| BP | IDA | GO:0006986 | response to unfolded protein |
| BP | IMP | GO:0008285 | negative regulation of cell proliferation |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IMP | GO:0010941 | regulation of cell death |
| BP | IMP | GO:0030308 | negative regulation of cell growth |
| BP | IMP | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway |
| BP | IDA | GO:0031396 | regulation of protein ubiquitination |
| BP | IDA | GO:0031397 | negative regulation of protein ubiquitination |
| BP | IBA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0032757 | positive regulation of interleukin-8 production |
| BP | IDA | GO:0033120 | positive regulation of RNA splicing |
| BP | TAS | GO:0034599 | cellular response to oxidative stress |
| BP | IBA | GO:0034605 | cellular response to heat |
| BP | IDA | GO:0034605 | cellular response to heat |
| BP | IBA | GO:0034620 | cellular response to unfolded protein |
| BP | IMP | GO:0034620 | cellular response to unfolded protein |
| BP | IBA | GO:0042026 | protein refolding |
| BP | IDA | GO:0042026 | protein refolding |
| BP | IMP | GO:0042026 | protein refolding |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | IMP | GO:0045648 | positive regulation of erythrocyte differentiation |
| BP | IDA | GO:0046034 | ATP metabolic process |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IDA | GO:0050821 | protein stabilization |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | TAS | GO:0050821 | protein stabilization |
| BP | IBA | GO:0051085 | chaperone cofactor-dependent protein refolding |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0051131 | chaperone-mediated protein complex assembly |
| BP | IMP | GO:0060548 | negative regulation of cell death |
| BP | IMP | GO:0070370 | cellular heat acclimation |
| BP | IMP | GO:0070434 | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
| BP | IMP | GO:0090063 | positive regulation of microtubule nucleation |
| BP | IDA | GO:0090084 | negative regulation of inclusion body assembly |
| BP | IDA | GO:0097201 | negative regulation of transcription from RNA polymerase II promoter in response to stress |
| BP | TAS | GO:1900034 | regulation of cellular response to heat |
| BP | IDA | GO:1901029 | negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| BP | IBA | GO:1901673 | regulation of mitotic spindle assembly |
| BP | IMP | GO:1901673 | regulation of mitotic spindle assembly |
| BP | IDA | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| BP | IDA | GO:1902380 | positive regulation of endoribonuclease activity |
| BP | IMP | GO:1903265 | positive regulation of tumor necrosis factor-mediated signaling pathway |
| BP | IMP | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
Gene expression in normal tissue: HSPA1A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HSPA1A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus |
| reactome | R-HSA-168330 | Viral RNP Complexes in the Host Cell Nucleus |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371497 | HSP90 chaperone cycle for steroid hormone receptors (SHR) |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-3371568 | Attenuation phase |
| reactome | R-HSA-3371571 | HSF1-dependent transactivation |
| reactome | R-HSA-450408 | AUF1 (hnRNP D0) binds and destabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| biocarta | arfpathway | tumor suppressor arf inhibits ribosomal biogenesis |
| biocarta | p53hypoxiapathway | hypoxia and p53 in the cardiovascular system |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | tidpathway | chaperones modulate interferon signaling pathway |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | p53downstreampathway | Direct p53 effectors |
| kegg | hsa03040 | Spliceosome - Homo sapiens (human) |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04141 | Protein processing in endoplasmic reticulum - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04213 | Longevity regulating pathway - multiple species - Homo sapiens (human) |
| kegg | hsa04612 | Antigen processing and presentation - Homo sapiens (human) |
| kegg | hsa04915 | Estrogen signaling pathway - Homo sapiens (human) |
| kegg | hsa05020 | Prion diseases - Homo sapiens (human) |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP2359 | Parkin-Ubiquitin Proteasomal System pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP384 | Apoptosis Modulation by HSP70 |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD146 | Elesclomol | 1 |
| iGMDRD210 | AC55649 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HSPA1A
CLASSFICATION
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