SET
Summary: The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:600960 Ensembl IDEnsembl:ENSG00000119335 HGNC IDHGNC:HGNC:10760 PHARMGKB IDPA35678 Map Location9q34.11 |
GO terms in SET
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Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
MF | IEA | GO:0003677 | DNA binding |
MF | TAS | GO:0004864 | protein phosphatase inhibitor activity |
MF | IPI | GO:0005515 | protein binding |
MF | TAS | GO:0019888 | protein phosphatase regulator activity |
MF | TAS | GO:0042393 | histone binding |
CC | HDA | GO:0005634 | nucleus |
Gene expression in normal tissue: SET
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SET
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Database | Pathway ID | Pathway Des. |
---|---|---|
reactome | R-HSA-1640170 | Cell Cycle |
reactome | R-HSA-2299718 | Condensation of Prophase Chromosomes |
reactome | R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA |
reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
reactome | R-HSA-68875 | Mitotic Prophase |
reactome | R-HSA-68886 | M Phase |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in SET
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
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No matching records found |