SET


Summary: The protein encoded by this gene inhibits acetylation of nucleosomes, especially histone H4, by histone acetylases (HAT). This inhibition is most likely accomplished by masking histone lysines from being acetylated, and the consequence is to silence HAT-dependent transcription. The encoded protein is part of a complex localized to the endoplasmic reticulum but is found in the nucleus and inhibits apoptosis following attack by cytotoxic T lymphocytes. This protein can also enhance DNA replication of the adenovirus genome. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in SET


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0003677 DNA binding
MF TAS GO:0004864 protein phosphatase inhibitor activity
MF IPI GO:0005515 protein binding
MF TAS GO:0019888 protein phosphatase regulator activity
MF TAS GO:0042393 histone binding
CC HDA GO:0005634 nucleus
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Gene expression in normal tissue: SET

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 9BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 12

Gene-drug pathway distribution

undefined6Mitosis1Apoptosis regulation1Chromatin histone acetylation1

Pathways in SET


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-2299718 Condensation of Prophase Chromosomes
reactome R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA
reactome R-HSA-450531 Regulation of mRNA stability by proteins that bind AU-rich elements
reactome R-HSA-68875 Mitotic Prophase
reactome R-HSA-68886 M Phase
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD77 Itraconazole 3
iGMDRD318 PAC-1 1
iGMDRD105 Triptolide 3
iGMDRD289 Parthenolide 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SET

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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