TMPRSS2
Summary: This gene encodes a protein that belongs to the serine protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic hormones in prostate cancer cells and down-regulated in androgen-independent prostate cancer tissue. The protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transmembrane serine protease 2 | MIM:602060 | Ensembl:ENSG00000184012 | HGNC:HGNC:11876 | PA36577 | 21q22.3 |
GO terms in TMPRSS2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004252 | serine-type endopeptidase activity |
| MF | IEA | GO:0005044 | scavenger receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0008236 | serine-type peptidase activity |
| BP | IDA | GO:0006508 | proteolysis |
| BP | IEA | GO:0006898 | receptor-mediated endocytosis |
| BP | IBA | GO:0016540 | protein autoprocessing |
| BP | IMP | GO:0016540 | protein autoprocessing |
| BP | IDA | GO:0046598 | positive regulation of viral entry into host cell |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005887 | integral component of plasma membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
Gene expression in normal tissue: TMPRSS2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TMPRSS2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| kegg | hsa05164 | Influenza A - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD105 | Triptolide | 4 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD945 | ML214 | 8 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD210 | AC55649 | 4 |
| iGMDRD577 | BIX01294 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TMPRSS2
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