HOXA11
Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| homeobox A11 | MIM:142958 | Ensembl:ENSG00000005073 | HGNC:HGNC:5101 | PA29378 | 7p15.2 |
Gene Categories:
TRANSCRIPTION FACTOR COMPLEXGO terms in HOXA11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | ISS | GO:0005667 | transcription factor complex |
| CC | ISS | GO:0032991 | protein-containing complex |
| CC | ISS | GO:0032993 | protein-DNA complex |
| BP | ISS | GO:0001501 | skeletal system development |
| BP | IEA | GO:0001656 | metanephros development |
| BP | ISS | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | IEA | GO:0001759 | organ induction |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0007275 | multicellular organism development |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0007338 | single fertilization |
| BP | ISS | GO:0007501 | mesodermal cell fate specification |
| BP | IEA | GO:0008584 | male gonad development |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | ISS | GO:0009953 | dorsal/ventral pattern formation |
| BP | IEA | GO:0009954 | proximal/distal pattern formation |
| BP | ISS | GO:0010720 | positive regulation of cell development |
| BP | ISS | GO:0030326 | embryonic limb morphogenesis |
| BP | ISS | GO:0032332 | positive regulation of chondrocyte differentiation |
| BP | IEA | GO:0035115 | embryonic forelimb morphogenesis |
| BP | IEA | GO:0042733 | embryonic digit morphogenesis |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | ISS | GO:0048589 | developmental growth |
| BP | IEA | GO:0060065 | uterus development |
| BP | IEA | GO:0060272 | embryonic skeletal joint morphogenesis |
| BP | ISS | GO:0060351 | cartilage development involved in endochondral bone morphogenesis |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0043565 | sequence-specific DNA binding |
Gene expression in normal tissue: HOXA11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in HOXA11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD679 | Bistramide A | 3 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in HOXA11
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