HOXA11


Summary: In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radio-ulnar synostosis with amegakaryocytic thrombocytopenia. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:142958
PHARMGKB IDPA29378
Map Location7p15.2

GO terms in HOXA11


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IDA GO:0005654 nucleoplasm
CC ISS GO:0005667 transcription factor complex
CC ISS GO:0032991 protein-containing complex
CC ISS GO:0032993 protein-DNA complex
BP ISS GO:0001501 skeletal system development
BP IEA GO:0001656 metanephros development
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Gene expression in normal tissue: HOXA11

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 15BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5

Gene-drug pathway distribution

undefined6Apoptosis regulation1Chromatin histone acetylation1

Pathways in HOXA11


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Database
Pathway ID
Pathway Des.
kegg hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD105 Triptolide 3
iGMDRD289 Parthenolide 1
iGMDRD318 PAC-1 1
iGMDRD210 AC55649 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in HOXA11

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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