TOX3


Summary: The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in TOX3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006351 transcription, DNA-templated
BP IEA GO:0006357 regulation of transcription by RNA polymerase II
BP IEA GO:0006915 apoptotic process
BP IDA GO:0042981 regulation of apoptotic process
BP IDA GO:0043524 negative regulation of neuron apoptotic process
BP IDA GO:0045893 positive regulation of transcription, DNA-templated
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Gene expression in normal tissue: TOX3

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 4undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 13undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9

Gene-drug pathway distribution

undefined6Cell cycle1Chromatin other1Apoptosis regulation1Chromatin histone acetylation1

Pathways in TOX3


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Database
Pathway ID
Pathway Des.
wikipathways WP2857 Mesodermal Commitment Pathway
wikipathways WP2858 Ectoderm Differentiation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD779 PRL-3 Inhibitor I 3
iGMDRD289 Parthenolide 1
iGMDRD105 Triptolide 6
iGMDRD318 PAC-1 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOX3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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