TOX3


Summary: The protein encoded by this gene contains an HMG-box, indicating that it may be involved in bending and unwinding of DNA and alteration of chromatin structure. The C-terminus of the encoded protein is glutamine-rich due to CAG repeats in the coding sequence. A minor allele of this gene has been implicated in an elevated risk of breast cancer. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
TOX high mobility group box family member 3MIM:611416Ensembl:ENSG00000103460HGNC:HGNC:11972PA16240675216q12.1

GO terms in TOX3


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPIEAGO:0006915apoptotic process
BPIDAGO:0042981regulation of apoptotic process
BPIDAGO:0043524negative regulation of neuron apoptotic process
BPIDAGO:0045893positive regulation of transcription, DNA-templated
CCIEAGO:0005634nucleus
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIDAGO:0003682chromatin binding
MFIPIGO:0005515protein binding
MFIDAGO:0034056estrogen response element binding
MFIDAGO:0042803protein homodimerization activity
MFIPIGO:0051219phosphoprotein binding

Gene expression in normal tissue: TOX3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TOX3


DatabasePathway IDPathway Des.
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP2858Ectoderm Differentiation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD779PRL-3 Inhibitor I3
iGMDRD289Parthenolide1
iGMDRD105Triptolide6
iGMDRD318PAC-13
iGMDRD8024-methylfasudil3
iGMDRD466Chaetocin1
iGMDRD945ML2143
iGMDRD662JQ-13
iGMDRD351GW843682X3
iGMDRD316N9-Isopropyl-olomoucine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOX3

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