PDK2

Summary: This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepyruvate dehydrogenase kinase 2
OMIM IDMIM:602525
Ensembl IDEnsembl:ENSG00000005882
HGNC IDHGNC:HGNC:8810
PHARMGKB IDPA33155
Map Location17q21.33

GO terms in PDK2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006006 glucose metabolic process
BP ISS GO:0006111 regulation of gluconeogenesis
BP IEA GO:0006468 protein phosphorylation
BP ISS GO:0006885 regulation of pH
BP ISS GO:0008286 insulin receptor signaling pathway
BP ISS GO:0010510 regulation of acetyl-CoA biosynthetic process from pyruvate
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Gene expression in normal tissue: PDK2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 9BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5

Gene-drug pathway distribution

undefined3Chromatin histone acetylation1Apoptosis regulation1

Pathways in PDK2


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Database
Pathway ID
Pathway Des.
biocarta eif4pathway regulation of eif-4e and p70s6 kinase
biocarta igf1mtorpathway skeletal muscle hypertrophy is regulated via akt-mtor pathway
biocarta mtorpathway mtor signaling pathway
biocarta ptenpathway pten dependent cell cycle arrest and apoptosis
reactome R-HSA-1428517 The citric acid (TCA) cycle and respiratory electron transport
reactome R-HSA-1430728 Metabolism
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD318 PAC-1 1
iGMDRD945 ML214 6
iGMDRD105 Triptolide 3
iGMDRD289 Parthenolide 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDK2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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