PDK2
Summary: This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pyruvate dehydrogenase kinase 2 | MIM:602525 | Ensembl:ENSG00000005882 | HGNC:HGNC:8810 | PA33155 | 17q21.33 |
GO terms in PDK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006006 | glucose metabolic process |
| BP | ISS | GO:0006111 | regulation of gluconeogenesis |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006885 | regulation of pH |
| BP | ISS | GO:0008286 | insulin receptor signaling pathway |
| BP | ISS | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate |
| BP | TAS | GO:0010510 | regulation of acetyl-CoA biosynthetic process from pyruvate |
| BP | ISS | GO:0010565 | regulation of cellular ketone metabolic process |
| BP | ISS | GO:0010906 | regulation of glucose metabolic process |
| BP | ISS | GO:0031670 | cellular response to nutrient |
| BP | IMP | GO:0034614 | cellular response to reactive oxygen species |
| BP | ISS | GO:0042593 | glucose homeostasis |
| BP | IEA | GO:0050848 | regulation of calcium-mediated signaling |
| BP | IMP | GO:0072332 | intrinsic apoptotic signaling pathway by p53 class mediator |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005759 | mitochondrial matrix |
| CC | IDA | GO:0005829 | cytosol |
| CC | ISS | GO:0005967 | mitochondrial pyruvate dehydrogenase complex |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | EXP | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| MF | IDA | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
Gene expression in normal tissue: PDK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | mtorpathway | mtor signaling pathway |
| biocarta | ptenpathway | pten dependent cell cycle arrest and apoptosis |
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex |
| reactome | R-HSA-5362517 | Signaling by Retinoic Acid |
| reactome | R-HSA-70268 | Pyruvate metabolism |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD945 | ML214 | 6 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDK2
CLASSFICATION
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