PDK2


Summary: This gene encodes a member of the pyruvate dehydrogenase kinase family. The encoded protein phosphorylates pyruvate dehydrogenase, down-regulating the activity of the mitochondrial pyruvate dehydrogenase complex. Overexpression of this gene may play a role in both cancer and diabetes. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
pyruvate dehydrogenase kinase 2MIM:602525Ensembl:ENSG00000005882HGNC:HGNC:8810PA3315517q21.33

GO terms in PDK2


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0006006glucose metabolic process
BPISSGO:0006111regulation of gluconeogenesis
BPIEAGO:0006468protein phosphorylation
BPISSGO:0006885regulation of pH
BPISSGO:0008286insulin receptor signaling pathway
BPISSGO:0010510regulation of acetyl-CoA biosynthetic process from pyruvate
BPTASGO:0010510regulation of acetyl-CoA biosynthetic process from pyruvate
BPISSGO:0010565regulation of cellular ketone metabolic process
BPISSGO:0010906regulation of glucose metabolic process
BPISSGO:0031670cellular response to nutrient
BPIMPGO:0034614cellular response to reactive oxygen species
BPISSGO:0042593glucose homeostasis
BPIEAGO:0050848regulation of calcium-mediated signaling
BPIMPGO:0072332intrinsic apoptotic signaling pathway by p53 class mediator
CCIDAGO:0005654nucleoplasm
CCIDAGO:0005739mitochondrion
CCTASGO:0005759mitochondrial matrix
CCIDAGO:0005829cytosol
CCISSGO:0005967mitochondrial pyruvate dehydrogenase complex
MFTASGO:0004672protein kinase activity
MFEXPGO:0004740pyruvate dehydrogenase (acetyl-transferring) kinase activity
MFIDAGO:0004740pyruvate dehydrogenase (acetyl-transferring) kinase activity
MFIDAGO:0005524ATP binding
MFIPIGO:0042803protein homodimerization activity

Gene expression in normal tissue: PDK2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in PDK2


DatabasePathway IDPathway Des.
biocartaeif4pathwayregulation of eif-4e and p70s6 kinase
biocartaigf1mtorpathwayskeletal muscle hypertrophy is regulated via akt-mtor pathway
biocartamtorpathwaymtor signaling pathway
biocartaptenpathwaypten dependent cell cycle arrest and apoptosis
reactomeR-HSA-1428517The citric acid (TCA) cycle and respiratory electron transport
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-204174Regulation of pyruvate dehydrogenase (PDH) complex
reactomeR-HSA-5362517Signaling by Retinoic Acid
reactomeR-HSA-70268Pyruvate metabolism
reactomeR-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycle
reactomeR-HSA-9006931Signaling by Nuclear Receptors

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD318PAC-11
iGMDRD945ML2146
iGMDRD105Triptolide3
iGMDRD289Parthenolide1
iGMDRD280CYTOCHALASIN B3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PDK2

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