FGF13
Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:300070 Ensembl IDEnsembl:ENSG00000129682 HGNC IDHGNC:HGNC:3670 PHARMGKB IDPA28109 Map LocationXq26.3-q27.1 | |||||
GO terms in FGF13
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0001764 | neuron migration |
| BP | ISS | GO:0006814 | sodium ion transport |
| BP | ISS | GO:0007026 | negative regulation of microtubule depolymerization |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007267 | cell-cell signaling |
Gene expression in normal tissue: FGF13
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FGF13
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| reactome | R-HSA-397014 | Muscle contraction |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FGF13
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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