FGF13


Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This gene is located in a region on chromosome X, which is associated with Borjeson-Forssman-Lehmann syndrome (BFLS), making it a possible candidate gene for familial cases of the BFLS, and for other syndromal and nonspecific forms of X-linked cognitive disability mapping to this region. Alternative splicing of this gene at the 5' end results in several transcript variants encoding different isoforms with different N-termini. [provided by RefSeq, Nov 2008].

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GO terms in FGF13


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0000165 MAPK cascade
BP ISS GO:0001764 neuron migration
BP ISS GO:0006814 sodium ion transport
BP ISS GO:0007026 negative regulation of microtubule depolymerization
BP TAS GO:0007165 signal transduction
BP TAS GO:0007267 cell-cell signaling
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Gene expression in normal tissue: FGF13

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined9Apoptosis regulation1One carbon pool by folate1Genome integrity1DNA replication1Biosynthesis of secondary metabolites1p53 pathway1RTK signaling1Chromatin other1

Pathways in FGF13


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Database
Pathway ID
Pathway Des.
wikipathways WP2882 Nuclear Receptors Meta-Pathway
wikipathways WP2884 NRF2 pathway
wikipathways WP382 MAPK Signaling Pathway
wikipathways WP4172 PI3K-Akt Signaling Pathway
wikipathways WP51 Regulation of Actin Cytoskeleton
reactome R-HSA-397014 Muscle contraction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD662 JQ-1 3
iGMDRD100 Zebularine 3
iGMDRD188 Piperlongumine 3
iGMDRD451 Serdemetan 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGF13

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Reference ID
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Cancer
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