EPX
Summary: This gene is a member of the peroxidase gene family and is expressed in eosinophils. The encoded preproprotein is proteolytically processed into covalently attached heavy and light chains to form the mature enzyme, which functions as an oxidant. The enzyme is released at sites of parasitic infection or allergen stimulation to mediate lysis of protozoa or parasitic worms. The gene is found in a gene cluster with other peroxidase genes on chromosome 17. Mutations in this gene result in eosinophil peroxidase deficiency. [provided by RefSeq, Feb 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| eosinophil peroxidase | MIM:131399 | Ensembl:ENSG00000121053 | HGNC:HGNC:3423 | PA27841 | 17q22 |
Gene Categories:
DRUGGABLE GENOMEGO terms in EPX
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004601 | peroxidase activity |
| MF | IEA | GO:0020037 | heme binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IBA | GO:0005615 | extracellular space |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0034774 | secretory granule lumen |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0002215 | defense response to nematode |
| BP | IEA | GO:0006979 | response to oxidative stress |
| BP | IEA | GO:0032693 | negative regulation of interleukin-10 production |
| BP | IEA | GO:0032714 | negative regulation of interleukin-5 production |
| BP | IEA | GO:0032753 | positive regulation of interleukin-4 production |
| BP | IBA | GO:0042742 | defense response to bacterium |
| BP | IEA | GO:0042744 | hydrogen peroxide catabolic process |
| BP | TAS | GO:0043312 | neutrophil degranulation |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | IEA | GO:0072677 | eosinophil migration |
| BP | IEA | GO:0098869 | cellular oxidant detoxification |
Gene expression in normal tissue: EPX
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in EPX
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa05310 | Asthma - Homo sapiens (human) |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-6798695 | Neutrophil degranulation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD889 | Compound 7d-cis | 6 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in EPX
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