SNAI1
Summary: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| snail family transcriptional repressor 1 | MIM:604238 | Ensembl:ENSG00000124216 | HGNC:HGNC:11128 | PA35977 | 20q13.13 |
GO terms in SNAI1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | ISS | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEP | GO:0001649 | osteoblast differentiation |
| BP | ISS | GO:0001707 | mesoderm formation |
| BP | IDA | GO:0001837 | epithelial to mesenchymal transition |
| BP | ISS | GO:0001837 | epithelial to mesenchymal transition |
| BP | TAS | GO:0003198 | epithelial to mesenchymal transition involved in endocardial cushion formation |
| BP | IMP | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | ISS | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | TAS | GO:0010718 | positive regulation of epithelial to mesenchymal transition |
| BP | IDA | GO:0010957 | negative regulation of vitamin D biosynthetic process |
| BP | IEA | GO:0016477 | cell migration |
| BP | IMP | GO:0030335 | positive regulation of cell migration |
| BP | IEA | GO:0031069 | hair follicle morphogenesis |
| BP | IMP | GO:0043518 | negative regulation of DNA damage response, signal transduction by p53 class mediator |
| BP | IMP | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IEA | GO:0060021 | roof of mouth development |
| BP | IEA | GO:0060536 | cartilage morphogenesis |
| BP | IEA | GO:0060707 | trophoblast giant cell differentiation |
| BP | IEA | GO:0060806 | negative regulation of cell differentiation involved in embryonic placenta development |
| BP | IEA | GO:0060972 | left/right pattern formation |
| BP | ISS | GO:0061314 | Notch signaling involved in heart development |
| BP | ISS | GO:0070828 | heterochromatin organization |
| BP | IMP | GO:1902230 | negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage |
| BP | IMP | GO:2000810 | regulation of bicellular tight junction assembly |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005721 | pericentric heterochromatin |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
Gene expression in normal tissue: SNAI1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SNAI1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-6807070 | PTEN Regulation |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-8943724 | Regulation of PTEN gene transcription |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| biocarta | mta3pathway | downregulated of mta-3 in er-negative breast tumors |
| kegg | hsa04520 | Adherens junction - Homo sapiens (human) |
| pid | ilk_pathway | Integrin-linked kinase signaling |
| pid | met_pathway | Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met) |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP304 | Kit receptor signaling pathway |
| wikipathways | WP3859 | TGF-B Signaling in Thyroid Cells for Epithelial-Mesenchymal Transition |
| wikipathways | WP4239 | EMT transition in Colorectal Cancer |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD35 | PD153035 | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD605 | AZD6482 | 1 |
| iGMDRD36 | Phloretin | 1 |
| iGMDRD561 | ABT-263 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SNAI1
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.