SNAI1

Summary: The Drosophila embryonic protein snail is a zinc finger transcriptional repressor which downregulates the expression of ectodermal genes within the mesoderm. The nuclear protein encoded by this gene is structurally similar to the Drosophila snail protein, and is also thought to be critical for mesoderm formation in the developing embryo. At least two variants of a similar processed pseudogene have been found on chromosome 2. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namesnail family transcriptional repressor 1
OMIM IDMIM:604238
Ensembl IDEnsembl:ENSG00000124216
HGNC IDHGNC:HGNC:11128
PHARMGKB IDPA35977
Map Location20q13.13

GO terms in SNAI1


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IEA GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF IPI GO:0005515 protein binding
MF IPI GO:0019900 kinase binding
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Gene expression in normal tissue: SNAI1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 3SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: undefined model num: 1LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Gene-drug pathway distribution

undefined3Apoptosis regulation2PI3K/MTOR signaling1

Pathways in SNAI1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1257604 PIP3 activates AKT signaling
reactome R-HSA-1257604 PIP3 activates AKT signaling
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-6807070 PTEN Regulation
reactome R-HSA-6807070 PTEN Regulation
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD297 Austocystin D 1
iGMDRD35 PD153035 1
iGMDRD318 PAC-1 1
iGMDRD605 AZD6482 1
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SNAI1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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