Summary: The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014].

tribbles pseudokinase 3MIM:607898Ensembl:ENSG00000101255HGNC:HGNC:16228PA2580420p13

GO terms in TRIB3

Term TypeEvidence TypeGO Term IDGO Des.
BPIDAGO:0000122negative regulation of transcription by RNA polymerase II
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006468protein phosphorylation
BPIDAGO:0006469negative regulation of protein kinase activity
BPISSGO:0010827regulation of glucose transmembrane transport
BPTASGO:0019216regulation of lipid metabolic process
BPISSGO:0032092positive regulation of protein binding
BPIBAGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic process
BPISSGO:0032869cellular response to insulin stimulus
BPIDAGO:0034976response to endoplasmic reticulum stress
BPIBAGO:0043405regulation of MAP kinase activity
BPIDAGO:0043405regulation of MAP kinase activity
BPISSGO:0045599negative regulation of fat cell differentiation
BPISSGO:0045717negative regulation of fatty acid biosynthetic process
BPIMPGO:0045892negative regulation of transcription, DNA-templated
BPISSGO:0051443positive regulation of ubiquitin-protein transferase activity
BPTASGO:0051898negative regulation of protein kinase B signaling
BPIDAGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
BPTASGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
CCTASGO:0005886plasma membrane
MFISSGO:0003714transcription corepressor activity
MFIEAGO:0004860protein kinase inhibitor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0016301kinase activity
MFIPIGO:0019901protein kinase binding
MFISSGO:0019901protein kinase binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFISSGO:0031625ubiquitin protein ligase binding
MFISSGO:0055106ubiquitin-protein transferase regulator activity

Gene expression in normal tissue: TRIB3

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRIB3

DatabasePathway IDPathway Des.
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1280218Adaptive Immune System
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-165158Activation of AKT2
reactomeR-HSA-168256Immune System
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-1989781PPARA activates gene expression
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-388841Costimulation by the CD28 family
reactomeR-HSA-389356CD28 co-stimulation
reactomeR-HSA-389357CD28 dependent PI3K/Akt signaling
reactomeR-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-5218920VEGFR2 mediated vascular permeability
reactomeR-HSA-556833Metabolism of lipids
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
kegghsa04931Insulin resistance - Homo sapiens (human)
wikipathwaysWP2797Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
wikipathwaysWP3613Photodynamic therapy-induced unfolded protein response
wikipathwaysWP481Insulin Signaling

Gene-Drug: Aster Plot

Drug IDDrug NameModel Num.

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRIB3