TRIB3

Summary: The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nametribbles pseudokinase 3
OMIM IDMIM:607898
Ensembl IDEnsembl:ENSG00000101255
HGNC IDHGNC:HGNC:16228
PHARMGKB IDPA25804
Map Location20p13

GO terms in TRIB3


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0000122 negative regulation of transcription by RNA polymerase II
BP IEA GO:0006351 transcription, DNA-templated
BP IEA GO:0006468 protein phosphorylation
BP IDA GO:0006469 negative regulation of protein kinase activity
BP ISS GO:0010827 regulation of glucose transmembrane transport
BP TAS GO:0019216 regulation of lipid metabolic process
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Gene expression in normal tissue: TRIB3

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 4BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 5

Gene-drug pathway distribution

undefined2Apoptosis regulation1Chromatin histone acetylation1

Pathways in TRIB3


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109704 PI3K Cascade
reactome R-HSA-112399 IRS-mediated signalling
reactome R-HSA-1257604 PIP3 activates AKT signaling
reactome R-HSA-1280218 Adaptive Immune System
reactome R-HSA-1430728 Metabolism
reactome R-HSA-162582 Signal Transduction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD577 BIX01294 1
iGMDRD289 Parthenolide 1
iGMDRD318 PAC-1 1
iGMDRD945 ML214 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRIB3

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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