TRIB3
Summary: The protein encoded by this gene is a putative protein kinase that is induced by the transcription factor NF-kappaB. The encoded protein is a negative regulator of NF-kappaB and can also sensitize cells to TNF- and TRAIL-induced apoptosis. In addition, this protein can negatively regulate the cell survival serine-threonine kinase AKT1. Differential promoter usage and alternate splicing result in multiple transcript variants. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tribbles pseudokinase 3 | MIM:607898 | Ensembl:ENSG00000101255 | HGNC:HGNC:16228 | PA25804 | 20p13 |
GO terms in TRIB3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006469 | negative regulation of protein kinase activity |
| BP | ISS | GO:0010827 | regulation of glucose transmembrane transport |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | ISS | GO:0032092 | positive regulation of protein binding |
| BP | IBA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | ISS | GO:0032869 | cellular response to insulin stimulus |
| BP | IDA | GO:0034976 | response to endoplasmic reticulum stress |
| BP | IBA | GO:0043405 | regulation of MAP kinase activity |
| BP | IDA | GO:0043405 | regulation of MAP kinase activity |
| BP | ISS | GO:0045599 | negative regulation of fat cell differentiation |
| BP | ISS | GO:0045717 | negative regulation of fatty acid biosynthetic process |
| BP | IMP | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | ISS | GO:0051443 | positive regulation of ubiquitin-protein transferase activity |
| BP | TAS | GO:0051898 | negative regulation of protein kinase B signaling |
| BP | IDA | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| BP | TAS | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| CC | IBA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | TAS | GO:0005829 | cytosol |
| CC | TAS | GO:0005886 | plasma membrane |
| MF | ISS | GO:0003714 | transcription corepressor activity |
| MF | IEA | GO:0004860 | protein kinase inhibitor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0016301 | kinase activity |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | ISS | GO:0019901 | protein kinase binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | ISS | GO:0031625 | ubiquitin protein ligase binding |
| MF | ISS | GO:0055106 | ubiquitin-protein transferase regulator activity |
Gene expression in normal tissue: TRIB3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIB3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-165158 | Activation of AKT2 |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194138 | Signaling by VEGF |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-199418 | Negative regulation of the PI3K/AKT network |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-388841 | Costimulation by the CD28 family |
| reactome | R-HSA-389356 | CD28 co-stimulation |
| reactome | R-HSA-389357 | CD28 dependent PI3K/Akt signaling |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-4420097 | VEGFA-VEGFR2 Pathway |
| reactome | R-HSA-5218920 | VEGFR2 mediated vascular permeability |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2797 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| wikipathways | WP3613 | Photodynamic therapy-induced unfolded protein response |
| wikipathways | WP481 | Insulin Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD945 | ML214 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIB3
CLASSFICATION
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