MSI2


Summary: This gene encodes an RNA-binding protein that is a member of the Musashi protein family. The encoded protein is transcriptional regulator that targets genes involved in development and cell cycle regulation. Mutations in this gene are associated with poor prognosis in certain types of cancers. This gene has also been shown to be rearranged in certain cancer cells. [provided by RefSeq, Apr 2016].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in MSI2


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Term Type
Evidence Type
GO Term ID
GO Des.
MF HDA GO:0003723 RNA binding
MF IBA GO:0003723 RNA binding
MF IPI GO:0005515 protein binding
MF IEA GO:0008266 poly(U) RNA binding
BP IEA GO:0048864 stem cell development
BP IBA GO:0051252 regulation of RNA metabolic process
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Gene expression in normal tissue: MSI2

Gene-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 3undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 6UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 6

Gene-drug pathway distribution

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Pathways in MSI2


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Database
Pathway ID
Pathway Des.
wikipathways WP2004 miR-targeted genes in lymphocytes - TarBase
kegg hsa03015 mRNA surveillance pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD280 CYTOCHALASIN B 3
iGMDRD318 PAC-1 3
iGMDRD871 BRD6368 3
iGMDRD126 Tipifarnib 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MSI2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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