iGMDRD940

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Standard Name
Drug Status
Drug Type
Standard NameMDM2/MDMX inhibitor
Drug StatusFamily
Drug Typeundefined

Drug-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: Sarcoma model num: 1EYtissue: EY cancer: EYE model num: 0EYEtissue: EYE cancer: Retinoblastoma (RBL) model num: 6SOFT_TISSUtissue: SOFT_TISSU cancer: SOFT_TISSUE model num: 0SOFT_TISSUEtissue: SOFT_TISSUE cancer: Sarcoma, NOS (SARCNOS) model num: 1

Drug-gene pathway enrichments

3reactome: Cell Cycle2reactome: Cellular responses to external stimuli2reactome: Gene expression (Transcription)2reactome: RNA Polymerase II Transcription2reactome: Inhibition of replication initiation of damaged DNA by RB1/E2F12reactome: Oncogene Induced Senescence2reactome: Mitotic G1-G1/S phases2reactome: E2F mediated regulation of DNA replication2reactome: G1/S Transition2reactome: Cell Cycle, Mitotic

Drug-gene GO enrichments

5CC: nucleus3CC: Rb-E2F complex3CC: nucleoplasm2BP: regulation of mitotic cell cycle2BP: negative regulation of G1/S transition of mitotic cell cycle2MF: protein binding2BP: negative regulation of transcription, DNA-templated2CC: chromatin2MF: RNA polymerase II activating transcription factor binding2BP: cell morphogenesis involved in neuron differentiation

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4194 MDM4 2
5925 RB1 6
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Gene in drug-gene network: Network Plot

Models in MDM2/MDMX inhibitor

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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