MSMB
Summary: The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| microseminoprotein beta | MIM:157145 | Ensembl:ENSG00000263639 | HGNC:HGNC:7372 | PA31177 | 10q11.22 |
Gene Categories:
DRUGGABLE GENOMEGO terms in MSMB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0005615 | extracellular space |
| CC | TAS | GO:0005634 | nucleus |
| BP | ND | GO:0008150 | biological_process |
| MF | ND | GO:0003674 | molecular_function |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: MSMB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MSMB
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD52 | Rotenone | 3 |
| iGMDRD248 | BRD4354 | 4 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD888 | Compound 44 | 4 |
| iGMDRD871 | BRD6368 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MSMB
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