CDK2
Summary: This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase 2 | MIM:116953 | Ensembl:ENSG00000123374 | HGNC:HGNC:1771 | PA101 | 12q13.2 |
GO terms in CDK2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | NAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006260 | DNA replication |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006813 | potassium ion transport |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | IMP | GO:0007099 | centriole replication |
| BP | IBA | GO:0007165 | signal transduction |
| BP | IEP | GO:0007265 | Ras protein signal transduction |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | IBA | GO:0008284 | positive regulation of cell proliferation |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | IBA | GO:0010033 | response to organic substance |
| BP | IBA | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | IBA | GO:0010468 | regulation of gene expression |
| BP | IDA | GO:0016572 | histone phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | TAS | GO:0031571 | mitotic G1 DNA damage checkpoint |
| BP | IEA | GO:0032298 | positive regulation of DNA-dependent DNA replication initiation |
| BP | IEA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | TAS | GO:0051298 | centrosome duplication |
| BP | IEA | GO:0051301 | cell division |
| BP | TAS | GO:0051321 | meiotic cell cycle |
| BP | IDA | GO:0060968 | regulation of gene silencing |
| BP | TAS | GO:0071732 | cellular response to nitric oxide |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| CC | IBA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IDA | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex |
| CC | IEA | GO:0000781 | chromosome, telomeric region |
| CC | IEA | GO:0000793 | condensed chromosome |
| CC | IEA | GO:0000805 | X chromosome |
| CC | IEA | GO:0000806 | Y chromosome |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005667 | transcription factor complex |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005768 | endosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | TAS | GO:0005813 | centrosome |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0015030 | Cajal body |
| CC | IEA | GO:0097123 | cyclin A1-CDK2 complex |
| CC | IDA | GO:0097124 | cyclin A2-CDK2 complex |
| CC | IEA | GO:0097134 | cyclin E1-CDK2 complex |
| CC | IEA | GO:0097135 | cyclin E2-CDK2 complex |
| MF | IGI | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IDA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | TAS | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019904 | protein domain specific binding |
| MF | IBA | GO:0030332 | cyclin binding |
| MF | IDA | GO:0030332 | cyclin binding |
| MF | IPI | GO:0030332 | cyclin binding |
| MF | IDA | GO:0035173 | histone kinase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0097472 | cyclin-dependent protein kinase activity |
Gene expression in normal tissue: CDK2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP179 | Cell Cycle |
| wikipathways | WP2032 | Human Thyroid Stimulating Hormone (TSH) signaling pathway |
| wikipathways | WP2261 | Signaling Pathways in Glioblastoma |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
| wikipathways | WP2586 | Aryl Hydrocarbon Receptor |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP45 | G1 to S cell cycle control |
| wikipathways | WP466 | DNA Replication |
| wikipathways | WP53 | ID signaling pathway |
| wikipathways | WP707 | DNA Damage Response |
| pid | atr_pathway | ATR signaling pathway |
| pid | bard1pathway | BARD1 signaling events |
| pid | e2f_pathway | E2F transcription factor network |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | foxopathway | FoxO family signaling |
| pid | il2_1pathway | IL2-mediated signaling events |
| pid | mtor_4pathway | mTOR signaling pathway |
| pid | p53regulationpathway | p53 pathway |
| pid | p73pathway | p73 transcription factor network |
| pid | prlsignalingeventspathway | Signaling events mediated by PRL |
| pid | rb_1pathway | Regulation of retinoblastoma protein |
| pid | smad2_3nuclearpathway | Regulation of nuclear SMAD2/3 signaling |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_ID | ID |
| netpath | Pathway_IL2 | IL2 |
| netpath | Pathway_KitReceptor | KitReceptor |
| netpath | Pathway_RAGE | RAGE |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04110 | Cell cycle - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05215 | Prostate cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
| biocarta | cellcyclepathway | cyclins and cell cycle regulation |
| biocarta | efppathway | estrogen responsive protein efp controls cell cycle and breast tumors growth |
| biocarta | fbw7pathway | cyclin e destruction pathway |
| biocarta | g1pathway | cell cycle: g1/s check point |
| biocarta | mcmpathway | cdk regulation of dna replication |
| biocarta | p27pathway | regulation of p27 phosphorylation during cell cycle progression |
| biocarta | p53pathway | p53 signaling pathway |
| biocarta | raccycdpathway | influence of ras and rho proteins on g1 to s transition |
| biocarta | rbpathway | rb tumor suppressor/checkpoint signaling in response to dna damage |
| biocarta | skp2e2fpathway | e2f1 destruction pathway |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-1538133 | G0 and Early G1 |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-174143 | APC/C-mediated degradation of cell cycle proteins |
| reactome | R-HSA-176187 | Activation of ATR in response to replication stress |
| reactome | R-HSA-176408 | Regulation of APC/C activators between G1/S and early anaphase |
| reactome | R-HSA-187577 | SCF(Skp2)-mediated degradation of p27/p21 |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559582 | Senescence-Associated Secretory Phenotype (SASP) |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-453276 | Regulation of mitotic cell cycle |
| reactome | R-HSA-453279 | Mitotic G1-G1/S phases |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804116 | TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-6804757 | Regulation of TP53 Degradation |
| reactome | R-HSA-6806003 | Regulation of TP53 Expression and Degradation |
| reactome | R-HSA-68874 | M/G1 Transition |
| reactome | R-HSA-68911 | G2 Phase |
| reactome | R-HSA-68949 | Orc1 removal from chromatin |
| reactome | R-HSA-68962 | Activation of the pre-replicative complex |
| reactome | R-HSA-69002 | DNA Replication Pre-Initiation |
| reactome | R-HSA-69017 | CDK-mediated phosphorylation and removal of Cdc6 |
| reactome | R-HSA-69052 | Switching of origins to a post-replicative state |
| reactome | R-HSA-69200 | Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes |
| reactome | R-HSA-69202 | Cyclin E associated events during G1/S transition |
| reactome | R-HSA-69206 | G1/S Transition |
| reactome | R-HSA-69239 | Synthesis of DNA |
| reactome | R-HSA-69242 | S Phase |
| reactome | R-HSA-69273 | Cyclin A/B1/B2 associated events during G2/M transition |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-69306 | DNA Replication |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69563 | p53-Dependent G1 DNA Damage Response |
| reactome | R-HSA-69580 | p53-Dependent G1/S DNA damage checkpoint |
| reactome | R-HSA-69615 | G1/S DNA Damage Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-69656 | Cyclin A:Cdk2-associated events at S phase entry |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8848021 | Signaling by PTK6 |
| reactome | R-HSA-8849470 | PTK6 Regulates Cell Cycle |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-9006927 | Signaling by Non-Receptor Tyrosine Kinases |
| reactome | R-HSA-912446 | Meiotic recombination |
| reactome | R-HSA-983231 | Factors involved in megakaryocyte development and platelet production |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD201 | SKI II | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK2
CLASSFICATION
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