MAPK12


Summary: Activation of members of the mitogen-activated protein kinase family is a major mechanism for transduction of extracellular signals. Stress-activated protein kinases are one subclass of MAP kinases. The protein encoded by this gene functions as a signal transducer during differentiation of myoblasts to myotubes. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase 12MIM:602399Ensembl:ENSG00000188130HGNC:HGNC:6874PA3061922q13.33

GO terms in MAPK12


Term TypeEvidence TypeGO Term IDGO Des.
BPIEAGO:0000165MAPK cascade
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPTASGO:0006975DNA damage induced protein phosphorylation
BPTASGO:0007050cell cycle arrest
BPTASGO:0007165signal transduction
BPTASGO:0007517muscle organ development
BPIBAGO:0010468regulation of gene expression
BPNASGO:0010952positive regulation of peptidase activity
BPIDAGO:0018105peptidyl-serine phosphorylation
BPTASGO:0018105peptidyl-serine phosphorylation
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0045445myoblast differentiation
BPTASGO:0051149positive regulation of muscle cell differentiation
BPIBAGO:0071310cellular response to organic substance
CCIBAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIEAGO:0005739mitochondrion
CCTASGO:0005829cytosol
MFIDAGO:0000287magnesium ion binding
MFIDAGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004707MAP kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding

Gene expression in normal tissue: MAPK12

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAPK12


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1592230Mitochondrial biogenesis
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-167044Signalling to RAS
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168638NOD1/2 Signaling Pathway
reactomeR-HSA-168643Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
reactomeR-HSA-171007p38MAPK events
reactomeR-HSA-1852241Organelle biogenesis and maintenance
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-187687Signalling to ERKs
reactomeR-HSA-194138Signaling by VEGF
reactomeR-HSA-2151209Activation of PPARGC1A (PGC-1alpha) by phosphorylation
reactomeR-HSA-373752Netrin-1 signaling
reactomeR-HSA-375170CDO in myogenesis
reactomeR-HSA-375170CDO in myogenesis
reactomeR-HSA-376172DSCAM interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-4420097VEGFA-VEGFR2 Pathway
reactomeR-HSA-525793Myogenesis
reactomeR-HSA-525793Myogenesis
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
biocartamapkpathwaymapkinase signaling pathway
pharmgkbPA2032VEGF Signaling Pathway
pidp38gammadeltapathwaySignaling mediated by p38-gamma and p38-delta
pidrhoa_pathwayRhoA signaling pathway
netpathPathway_KitReceptorKitReceptor
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04068FoxO signaling pathway - Homo sapiens (human)
kegghsa04071Sphingolipid signaling pathway - Homo sapiens (human)
kegghsa04114Oocyte meiosis - Homo sapiens (human)
kegghsa04218Cellular senescence - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04370VEGF signaling pathway - Homo sapiens (human)
kegghsa04380Osteoclast differentiation - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04611Platelet activation - Homo sapiens (human)
kegghsa04620Toll-like receptor signaling pathway - Homo sapiens (human)
kegghsa04621NOD-like receptor signaling pathway - Homo sapiens (human)
kegghsa04622RIG-I-like receptor signaling pathway - Homo sapiens (human)
kegghsa04625C-type lectin receptor signaling pathway - Homo sapiens (human)
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
kegghsa04658Th1 and Th2 cell differentiation - Homo sapiens (human)
kegghsa04659Th17 cell differentiation - Homo sapiens (human)
kegghsa04660T cell receptor signaling pathway - Homo sapiens (human)
kegghsa04664Fc epsilon RI signaling pathway - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04670Leukocyte transendothelial migration - Homo sapiens (human)
kegghsa04714Thermogenesis - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa04723Retrograde endocannabinoid signaling - Homo sapiens (human)
kegghsa04728Dopaminergic synapse - Homo sapiens (human)
kegghsa04750Inflammatory mediator regulation of TRP channels - Homo sapiens (human)
kegghsa04912GnRH signaling pathway - Homo sapiens (human)
kegghsa04914Progesterone-mediated oocyte maturation - Homo sapiens (human)
kegghsa04917Prolactin signaling pathway - Homo sapiens (human)
kegghsa04926Relaxin signaling pathway - Homo sapiens (human)
kegghsa04933AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
kegghsa05014Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human)
kegghsa05120Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human)
kegghsa05131Shigellosis - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05133Pertussis - Homo sapiens (human)
kegghsa05140Leishmaniasis - Homo sapiens (human)
kegghsa05142Chagas disease (American trypanosomiasis) - Homo sapiens (human)
kegghsa05145Toxoplasmosis - Homo sapiens (human)
kegghsa05152Tuberculosis - Homo sapiens (human)
kegghsa05160Hepatitis C - Homo sapiens (human)
kegghsa05164Influenza A - Homo sapiens (human)
kegghsa05167Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
kegghsa05418Fluid shear stress and atherosclerosis - Homo sapiens (human)
wikipathwaysWP1449Regulation of toll-like receptor signaling pathway
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP2004miR-targeted genes in lymphocytes - TarBase
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2371Parkinsons Disease Pathway
wikipathwaysWP26Signal Transduction of S1P Receptor
wikipathwaysWP3303Rac1-Pak1-p38-MMP-2 pathway
wikipathwaysWP3611Photodynamic therapy-induced AP-1 survival signaling.
wikipathwaysWP3612Photodynamic therapy-induced NFE2L2 (NRF2) survival signaling
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3865RIG-I-like Receptor Signaling
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3980Protein alkylation leading to liver fibrosis
wikipathwaysWP422MAPK Cascade
wikipathwaysWP4239EMT transition in Colorectal Cancer
wikipathwaysWP481Insulin Signaling
wikipathwaysWP75Toll-like Receptor Signaling Pathway

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD483SCH-5290743
iGMDRD289Parthenolide3
iGMDRD883CIL55A1
iGMDRD394BX-7953
iGMDRD64Parbendazole3
iGMDRD300Tozasertib3
iGMDRD193Fqi13
iGMDRD499PDMP3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPK12

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