OGG1
Summary: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:601982 Ensembl IDEnsembl:ENSG00000114026 HGNC IDHGNC:HGNC:8125 PHARMGKB IDPA31912 Map Location3p25.3 | |||||
GO terms in OGG1
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003684 | damaged DNA binding |
| MF | TAS | GO:0004519 | endonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IBA | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity |
| MF | TAS | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity |
Gene expression in normal tissue: OGG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OGG1
Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| reactome | R-HSA-110329 | Cleavage of the damaged pyrimidine |
| reactome | R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected purine |
| reactome | R-HSA-110331 | Cleavage of the damaged purine |
| reactome | R-HSA-110357 | Displacement of DNA glycosylase by APEX1 |
| reactome | R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OGG1
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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