OGG1
Summary: This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| 8-oxoguanine DNA glycosylase | MIM:601982 | Ensembl:ENSG00000114026 | HGNC:HGNC:8125 | PA31912 | 3p25.3 |
GO terms in OGG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0003684 | damaged DNA binding |
| MF | TAS | GO:0004519 | endonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008017 | microtubule binding |
| MF | IBA | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity |
| MF | TAS | GO:0008534 | oxidized purine nucleobase lesion DNA N-glycosylase activity |
| MF | IBA | GO:0019104 | DNA N-glycosylase activity |
| MF | IBA | GO:0032357 | oxidized purine DNA binding |
| MF | IDA | GO:0032357 | oxidized purine DNA binding |
| MF | IBA | GO:0034039 | 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity |
| MF | IEA | GO:0034039 | 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity |
| MF | IEA | GO:0140078 | class I DNA-(apurinic or apyrimidinic site) endonuclease activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005739 | mitochondrion |
| CC | IDA | GO:0016363 | nuclear matrix |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0032991 | protein-containing complex |
| BP | IEA | GO:0002526 | acute inflammatory response |
| BP | IBA | GO:0006284 | base-excision repair |
| BP | TAS | GO:0006284 | base-excision repair |
| BP | IBA | GO:0006285 | base-excision repair, AP site formation |
| BP | IMP | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IGI | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IDA | GO:0006979 | response to oxidative stress |
| BP | IBA | GO:0007004 | telomere maintenance via telomerase |
| BP | IEA | GO:0007568 | aging |
| BP | IDA | GO:0009314 | response to radiation |
| BP | IEA | GO:0009416 | response to light stimulus |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IDA | GO:0033683 | nucleotide-excision repair, DNA incision |
| BP | IEA | GO:0043066 | negative regulation of apoptotic process |
| BP | TAS | GO:0045007 | depurination |
| BP | TAS | GO:0045008 | depyrimidination |
| BP | IEA | GO:0045471 | response to ethanol |
| BP | IEA | GO:0051593 | response to folic acid |
| BP | IEA | GO:0071276 | cellular response to cadmium ion |
| BP | IDA | GO:1901291 | negative regulation of double-strand break repair via single-strand annealing |
Gene expression in normal tissue: OGG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in OGG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-110328 | Recognition and association of DNA glycosylase with site containing an affected pyrimidine |
| reactome | R-HSA-110329 | Cleavage of the damaged pyrimidine |
| reactome | R-HSA-110330 | Recognition and association of DNA glycosylase with site containing an affected purine |
| reactome | R-HSA-110331 | Cleavage of the damaged purine |
| reactome | R-HSA-110357 | Displacement of DNA glycosylase by APEX1 |
| reactome | R-HSA-5649702 | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway |
| reactome | R-HSA-73884 | Base Excision Repair |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-73927 | Depurination |
| reactome | R-HSA-73928 | Depyrimidination |
| reactome | R-HSA-73929 | Base-Excision Repair, AP Site Formation |
| reactome | R-HSA-73933 | Resolution of Abasic Sites (AP sites) |
| kegg | hsa03410 | Base excision repair - Homo sapiens (human) |
| pid | tap63pathway | Validated transcriptional targets of TAp63 isoforms |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD889 | Compound 7d-cis | 5 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in OGG1
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