RPS6KB2


Summary: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation. [provided by RefSeq, Jan 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in RPS6KB2


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Term Type
Evidence Type
GO Term ID
GO Des.
BP TAS GO:0006412 translation
BP IBA GO:0006468 protein phosphorylation
BP IEA GO:0006468 protein phosphorylation
BP TAS GO:0007165 signal transduction
BP IBA GO:0035556 intracellular signal transduction
BP IEA GO:0043491 protein kinase B signaling
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Gene expression in normal tissue: RPS6KB2

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 3OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 3

Gene-drug pathway distribution

Pathways in RPS6KB2


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Database
Pathway ID
Pathway Des.
kegg hsa04012 ErbB signaling pathway - Homo sapiens (human)
kegg hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
kegg hsa04140 Autophagy - animal - Homo sapiens (human)
kegg hsa04150 mTOR signaling pathway - Homo sapiens (human)
kegg hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
kegg hsa04152 AMPK signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD286 Nsc 632839 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS6KB2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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