MKNK1
Summary: This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MAP kinase interacting serine/threonine kinase 1 | MIM:606724 | Ensembl:ENSG00000079277 | HGNC:HGNC:7110 | PA30829 | 1p33 |
GO terms in MKNK1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006417 | regulation of translation |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IBA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | IDA | GO:0035556 | intracellular signal transduction |
| BP | IBA | GO:0046777 | protein autophosphorylation |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IBA | GO:0004683 | calmodulin-dependent protein kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0005516 | calmodulin binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IBA | GO:0009931 | calcium-dependent protein serine/threonine kinase activity |
| MF | IEA | GO:0046872 | metal ion binding |
Gene expression in normal tissue: MKNK1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MKNK1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | p38alphabetadownstreampathway | Signaling mediated by p38-alpha and p38-beta |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04910 | Insulin signaling pathway - Homo sapiens (human) |
| netpath | Pathway_IL2 | IL2 |
| wikipathways | WP2637 | Structural Pathway of Interleukin 1 (IL-1) |
| wikipathways | WP3676 | BDNF-TrkB Signaling |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3879 | 4-hydroxytamoxifen, Dexamethasone, and Retinoic Acids Regulation of p27 Expression |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP400 | p38 MAPK Signaling Pathway |
| reactome | R-HSA-1295596 | Spry regulation of FGF signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-190236 | Signaling by FGFR |
| reactome | R-HSA-5654726 | Negative regulation of FGFR1 signaling |
| reactome | R-HSA-5654727 | Negative regulation of FGFR2 signaling |
| reactome | R-HSA-5654732 | Negative regulation of FGFR3 signaling |
| reactome | R-HSA-5654733 | Negative regulation of FGFR4 signaling |
| reactome | R-HSA-5654736 | Signaling by FGFR1 |
| reactome | R-HSA-5654738 | Signaling by FGFR2 |
| reactome | R-HSA-5654741 | Signaling by FGFR3 |
| reactome | R-HSA-5654743 | Signaling by FGFR4 |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | eif4pathway | regulation of eif-4e and p70s6 kinase |
| biocarta | erkpathway | erk1/erk2 mapk signaling pathway |
| biocarta | igf1mtorpathway | skeletal muscle hypertrophy is regulated via akt-mtor pathway |
| biocarta | mtorpathway | mtor signaling pathway |
| biocarta | p38mapkpathway | p38 mapk signaling pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD144 | NSC95397 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MKNK1
CLASSFICATION
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