SEARCH

HOME / SEARCH / MKNK1

MKNK1

Summary: This gene encodes a Ser/Thr protein kinase that interacts with, and is activated by ERK1 and p38 mitogen-activated protein kinases, and thus may play a role in the response to environmental stress and cytokines. This kinase may also regulate transcription by phosphorylating eIF4E via interaction with the C-terminal region of eIF4G. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Jan 2012].

Loading, please wait...

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameMAP kinase interacting serine/threonine kinase 1 OMIM IDMIM:606724 Ensembl IDEnsembl:ENSG00000079277 HGNC IDHGNC:HGNC:7110 PHARMGKB IDPA30829 Map Location1p33

Gene Categories:

KINASE SERINE THREONINE KINASE DRUGGABLE GENOME

GO terms in MKNK1

Loading, please wait...

Term Type	Evidence Type	GO Term ID	GO Des.
BP	IEA	GO:0006417	regulation of translation
BP	IDA	GO:0006468	protein phosphorylation
BP	IBA	GO:0018105	peptidyl-serine phosphorylation
BP	IDA	GO:0018105	peptidyl-serine phosphorylation
BP	IBA	GO:0035556	intracellular signal transduction
BP	IDA	GO:0035556	intracellular signal transduction

Showing 1 to 6 of 19 rows rows per page

Gene expression in normal tissue: MKNK1

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MKNK1

Loading, please wait...

Database	Pathway ID	Pathway Des.
pid	p38alphabetadownstreampathway	Signaling mediated by p38-alpha and p38-beta
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04066	HIF-1 signaling pathway - Homo sapiens (human)
kegg	hsa04910	Insulin signaling pathway - Homo sapiens (human)
netpath	Pathway_IL2	IL2
wikipathways	WP2637	Structural Pathway of Interleukin 1 (IL-1)

Showing 1 to 6 of 28 rows rows per page

Gene-Drug: Aster Plot

Loading, please wait...

Drug ID	Drug Name	Model Num.
iGMDRD193	Fqi1	3
iGMDRD286	Nsc 632839	3
iGMDRD341	Triacsin c	3
iGMDRD872	BRD7137	3

Showing 1 to 4 of 12 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MKNK1

Loading, please wait...

	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
No matching records found

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.