TRIB2
Summary: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| tribbles pseudokinase 2 | MIM:609462 | Ensembl:ENSG00000071575 | HGNC:HGNC:30809 | PA128394647 | 2p24.3 |
GO terms in TRIB2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | NAS | GO:0006469 | negative regulation of protein kinase activity |
| BP | IBA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | ISS | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0043405 | regulation of MAP kinase activity |
| BP | ISS | GO:0043405 | regulation of MAP kinase activity |
| BP | IMP | GO:0045081 | negative regulation of interleukin-10 biosynthetic process |
| BP | ISS | GO:0045599 | negative regulation of fat cell differentiation |
| CC | IBA | GO:0005634 | nucleus |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0005856 | cytoskeleton |
| MF | ISS | GO:0000166 | nucleotide binding |
| MF | ISS | GO:0004672 | protein kinase activity |
| MF | IEA | GO:0004860 | protein kinase inhibitor activity |
| MF | ISS | GO:0008134 | transcription factor binding |
| MF | IBA | GO:0031434 | mitogen-activated protein kinase kinase binding |
| MF | ISS | GO:0031625 | ubiquitin protein ligase binding |
| MF | ISS | GO:0055106 | ubiquitin-protein transferase regulator activity |
Gene expression in normal tissue: TRIB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIB2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD188 | Piperlongumine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIB2
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