TRIB2
Summary: This gene encodes one of three members of the Tribbles family. The Tribbles members share a Trb domain, which is homologous to protein serine-threonine kinases, but lacks the active site lysine and probably lacks a catalytic function. The Tribbles proteins interact and modulate the activity of signal transduction pathways in a number of physiological and pathological processes. This Tribbles member induces apoptosis of cells mainly of the hematopoietic origin. It has been identified as a protein up-regulated by inflammatory stimuli in myeloid (THP-1) cells, and also as an oncogene that inactivates the transcription factor C/EBPalpha (CCAAT/enhancer-binding protein alpha) and causes acute myelogenous leukemia. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:609462 Ensembl IDEnsembl:ENSG00000071575 HGNC IDHGNC:HGNC:30809 PHARMGKB IDPA128394647 Map Location2p24.3 | |||||
GO terms in TRIB2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | NAS | GO:0006469 | negative regulation of protein kinase activity |
| BP | IBA | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | ISS | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IBA | GO:0043405 | regulation of MAP kinase activity |
| BP | ISS | GO:0043405 | regulation of MAP kinase activity |
Gene expression in normal tissue: TRIB2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRIB2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRIB2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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