NONO

Summary: This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namenon-POU domain containing octamer binding
OMIM IDMIM:300084
Ensembl IDEnsembl:ENSG00000147140
HGNC IDHGNC:HGNC:7871
PHARMGKB IDPA31680
Map LocationXq13.1

GO terms in NONO


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0000976 transcription regulatory region sequence-specific DNA binding
MF ISS GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IBA GO:0003676 nucleic acid binding
MF ISS GO:0003682 chromatin binding
MF HDA GO:0003723 RNA binding
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Gene expression in normal tissue: NONO

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 27BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 13

Gene-drug pathway distribution

Pathways in NONO


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Database
Pathway ID
Pathway Des.
biocarta antisensepathway antisense pathway
pid circadianpathway Circadian rhythm pathway
netpath Pathway_AndrogenReceptor AndrogenReceptor
wikipathways WP411 mRNA Processing
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD353 PD0325901 1
iGMDRD23 Gossypol 1
iGMDRD524 ISX-9 1
iGMDRD577 BIX01294 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NONO

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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