NONO


Summary: This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
non-POU domain containing octamer bindingMIM:300084Ensembl:ENSG00000147140HGNC:HGNC:7871PA31680Xq13.1

GO terms in NONO


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000976transcription regulatory region sequence-specific DNA binding
MFISSGO:0000980RNA polymerase II distal enhancer sequence-specific DNA binding
MFISAGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0003676nucleic acid binding
MFISSGO:0003682chromatin binding
MFHDAGO:0003723RNA binding
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFISSGO:0070888E-box binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCISSGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCIEAGO:0005730nucleolus
CCHDAGO:0016020membrane
CCIDAGO:0016363nuclear matrix
CCIEAGO:0016607nuclear speck
CCIDAGO:0042382paraspeckles
CCISSGO:0090575RNA polymerase II transcription factor complex
BPIBAGO:0000398mRNA splicing, via spliceosome
BPIDAGO:0002218activation of innate immune response
BPIEAGO:0006281DNA repair
BPIEAGO:0006310DNA recombination
BPIEAGO:0006351transcription, DNA-templated
BPIBAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0006357regulation of transcription by RNA polymerase II
BPTASGO:0006397mRNA processing
BPISSGO:0007623circadian rhythm
BPTASGO:0008380RNA splicing
BPISSGO:0042752regulation of circadian rhythm
BPIEAGO:0045087innate immune response
BPISSGO:0045892negative regulation of transcription, DNA-templated
BPIDAGO:1903377negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

Gene expression in normal tissue: NONO

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NONO


DatabasePathway IDPathway Des.
biocartaantisensepathwayantisense pathway
pidcircadianpathwayCircadian rhythm pathway
netpathPathway_AndrogenReceptorAndrogenReceptor
wikipathwaysWP411mRNA Processing

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD353PD03259011
iGMDRD23Gossypol1
iGMDRD524ISX-91
iGMDRD577BIX012943
iGMDRD780PP-303
iGMDRD871BRD63686
iGMDRD494Neopeltolide4
iGMDRD52Rotenone6
iGMDRD560MK-22063
iGMDRD599Salermide3
iGMDRD772BRD47703
iGMDRD330BRD41326

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NONO

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