NONO
Summary: This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| non-POU domain containing octamer binding | MIM:300084 | Ensembl:ENSG00000147140 | HGNC:HGNC:7871 | PA31680 | Xq13.1 |
GO terms in NONO
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | ISS | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0003676 | nucleic acid binding |
| MF | ISS | GO:0003682 | chromatin binding |
| MF | HDA | GO:0003723 | RNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | ISS | GO:0070888 | E-box binding |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005730 | nucleolus |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0016363 | nuclear matrix |
| CC | IEA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0042382 | paraspeckles |
| CC | ISS | GO:0090575 | RNA polymerase II transcription factor complex |
| BP | IBA | GO:0000398 | mRNA splicing, via spliceosome |
| BP | IDA | GO:0002218 | activation of innate immune response |
| BP | IEA | GO:0006281 | DNA repair |
| BP | IEA | GO:0006310 | DNA recombination |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006397 | mRNA processing |
| BP | ISS | GO:0007623 | circadian rhythm |
| BP | TAS | GO:0008380 | RNA splicing |
| BP | ISS | GO:0042752 | regulation of circadian rhythm |
| BP | IEA | GO:0045087 | innate immune response |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IDA | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
Gene expression in normal tissue: NONO
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NONO
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | antisensepathway | antisense pathway |
| pid | circadianpathway | Circadian rhythm pathway |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| wikipathways | WP411 | mRNA Processing |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD23 | Gossypol | 1 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD871 | BRD6368 | 6 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD52 | Rotenone | 6 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD330 | BRD4132 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NONO
CLASSFICATION
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