PARK7
Summary: The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| Parkinsonism associated deglycase | MIM:602533 | Ensembl:ENSG00000116288 | HGNC:HGNC:16369 | PA32946 | 1p36.23 |
GO terms in PARK7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000785 | chromatin |
| CC | HDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | IMP | GO:0005739 | mitochondrion |
| CC | IDA | GO:0005747 | mitochondrial respiratory chain complex I |
| CC | IEA | GO:0005758 | mitochondrial intermembrane space |
| CC | IEA | GO:0005759 | mitochondrial matrix |
| CC | IEA | GO:0005783 | endoplasmic reticulum |
| CC | IBA | GO:0005829 | cytosol |
| CC | IDA | GO:0005829 | cytosol |
| CC | IMP | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005913 | cell-cell adherens junction |
| CC | IDA | GO:0016605 | PML body |
| CC | ISS | GO:0030424 | axon |
| CC | IEA | GO:0044297 | cell body |
| CC | IEA | GO:0045121 | membrane raft |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IEA | GO:0098793 | presynapse |
| BP | IGI | GO:0001933 | negative regulation of protein phosphorylation |
| BP | ISS | GO:0002866 | positive regulation of acute inflammatory response to antigenic stimulus |
| BP | IDA | GO:0006281 | DNA repair |
| BP | IGI | GO:0006469 | negative regulation of protein kinase activity |
| BP | IEA | GO:0006508 | proteolysis |
| BP | IDA | GO:0006517 | protein deglycosylation |
| BP | IDA | GO:0006517 | protein deglycosylation |
| BP | IMP | GO:0006517 | protein deglycosylation |
| BP | IEA | GO:0006914 | autophagy |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | ISS | GO:0007005 | mitochondrion organization |
| BP | TAS | GO:0007265 | Ras protein signal transduction |
| BP | IEA | GO:0007338 | single fertilization |
| BP | IEA | GO:0008344 | adult locomotory behavior |
| BP | IDA | GO:0009438 | methylglyoxal metabolic process |
| BP | IDA | GO:0009438 | methylglyoxal metabolic process |
| BP | IMP | GO:0010273 | detoxification of copper ion |
| BP | TAS | GO:0010628 | positive regulation of gene expression |
| BP | IDA | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0018323 | enzyme active site formation via L-cysteine sulfinic acid |
| BP | IDA | GO:0019249 | lactate biosynthetic process |
| BP | ISS | GO:0030073 | insulin secretion |
| BP | IDA | GO:0031397 | negative regulation of protein ubiquitination |
| BP | IDA | GO:0032091 | negative regulation of protein binding |
| BP | IGI | GO:0032091 | negative regulation of protein binding |
| BP | IMP | GO:0032091 | negative regulation of protein binding |
| BP | IC | GO:0032148 | activation of protein kinase B activity |
| BP | IDA | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IDA | GO:0032757 | positive regulation of interleukin-8 production |
| BP | IMP | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | IDA | GO:0033234 | negative regulation of protein sumoylation |
| BP | ISS | GO:0033864 | positive regulation of NAD(P)H oxidase activity |
| BP | IDA | GO:0034599 | cellular response to oxidative stress |
| BP | IMP | GO:0034599 | cellular response to oxidative stress |
| BP | IDA | GO:0036471 | cellular response to glyoxal |
| BP | IDA | GO:0036526 | peptidyl-cysteine deglycation |
| BP | IDA | GO:0036527 | peptidyl-arginine deglycation |
| BP | IDA | GO:0036528 | peptidyl-lysine deglycation |
| BP | IBA | GO:0036529 | protein deglycation, glyoxal removal |
| BP | IDA | GO:0036529 | protein deglycation, glyoxal removal |
| BP | IDA | GO:0036530 | protein deglycation, methylglyoxal removal |
| BP | IDA | GO:0036530 | protein deglycation, methylglyoxal removal |
| BP | IDA | GO:0036531 | glutathione deglycation |
| BP | ISS | GO:0042593 | glucose homeostasis |
| BP | IDA | GO:0042743 | hydrogen peroxide metabolic process |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043523 | regulation of neuron apoptotic process |
| BP | IDA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IMP | GO:0045560 | regulation of TRAIL receptor biosynthetic process |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IGI | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0046295 | glycolate biosynthetic process |
| BP | IGI | GO:0046826 | negative regulation of protein export from nucleus |
| BP | ISS | GO:0050727 | regulation of inflammatory response |
| BP | IMP | GO:0050787 | detoxification of mercury ion |
| BP | IDA | GO:0050821 | protein stabilization |
| BP | IMP | GO:0050821 | protein stabilization |
| BP | IMP | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | TAS | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | IDA | GO:0051444 | negative regulation of ubiquitin-protein transferase activity |
| BP | IEA | GO:0051583 | dopamine uptake involved in synaptic transmission |
| BP | IMP | GO:0051881 | regulation of mitochondrial membrane potential |
| BP | IC | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0051899 | membrane depolarization |
| BP | IEA | GO:0060081 | membrane hyperpolarization |
| BP | IDA | GO:0060548 | negative regulation of cell death |
| BP | IDA | GO:0060765 | regulation of androgen receptor signaling pathway |
| BP | IDA | GO:0070301 | cellular response to hydrogen peroxide |
| BP | IDA | GO:0090073 | positive regulation of protein homodimerization activity |
| BP | IEA | GO:0098869 | cellular oxidant detoxification |
| BP | IDA | GO:0106044 | guanine deglycation |
| BP | IDA | GO:0106045 | guanine deglycation, methylglyoxal removal |
| BP | IBA | GO:0106046 | guanine deglycation, glyoxal removal |
| BP | IDA | GO:0106046 | guanine deglycation, glyoxal removal |
| BP | IDA | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | IMP | GO:1900182 | positive regulation of protein localization to nucleus |
| BP | IDA | GO:1901215 | negative regulation of neuron death |
| BP | IDA | GO:1901671 | positive regulation of superoxide dismutase activity |
| BP | IDA | GO:1901984 | negative regulation of protein acetylation |
| BP | IEA | GO:1902177 | positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway |
| BP | IGI | GO:1902236 | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway |
| BP | TAS | GO:1902903 | regulation of supramolecular fiber organization |
| BP | IMP | GO:1902958 | positive regulation of mitochondrial electron transport, NADH to ubiquinone |
| BP | IC | GO:1903073 | negative regulation of death-inducing signaling complex assembly |
| BP | IDA | GO:1903094 | negative regulation of protein K48-linked deubiquitination |
| BP | IMP | GO:1903122 | negative regulation of TRAIL-activated apoptotic signaling pathway |
| BP | IDA | GO:1903168 | positive regulation of pyrroline-5-carboxylate reductase activity |
| BP | IDA | GO:1903178 | positive regulation of tyrosine 3-monooxygenase activity |
| BP | IC | GO:1903181 | positive regulation of dopamine biosynthetic process |
| BP | IDA | GO:1903181 | positive regulation of dopamine biosynthetic process |
| BP | IDA | GO:1903189 | glyoxal metabolic process |
| BP | IMP | GO:1903197 | positive regulation of L-dopa biosynthetic process |
| BP | IDA | GO:1903200 | positive regulation of L-dopa decarboxylase activity |
| BP | IDA | GO:1903202 | negative regulation of oxidative stress-induced cell death |
| BP | IMP | GO:1903206 | negative regulation of hydrogen peroxide-induced cell death |
| BP | IDA | GO:1903208 | negative regulation of hydrogen peroxide-induced neuron death |
| BP | IDA | GO:1903377 | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway |
| BP | IGI | GO:1903384 | negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway |
| BP | ISS | GO:1903427 | negative regulation of reactive oxygen species biosynthetic process |
| BP | IEA | GO:1903428 | positive regulation of reactive oxygen species biosynthetic process |
| BP | NAS | GO:1903599 | positive regulation of autophagy of mitochondrion |
| BP | IDA | GO:1905259 | negative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway |
| BP | IDA | GO:2000157 | negative regulation of ubiquitin-specific protease activity |
| BP | IEA | GO:2000277 | positive regulation of oxidative phosphorylation uncoupler activity |
| BP | IMP | GO:2000679 | positive regulation of transcription regulatory region DNA binding |
| BP | IMP | GO:2000825 | positive regulation of androgen receptor activity |
| BP | IMP | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| BP | IMP | GO:2001268 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway |
| MF | IC | GO:0001047 | core promoter binding |
| MF | IDA | GO:0003690 | double-stranded DNA binding |
| MF | IDA | GO:0003697 | single-stranded DNA binding |
| MF | IGI | GO:0003713 | transcription coactivator activity |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0003729 | mRNA binding |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IDA | GO:0005507 | copper ion binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0008233 | peptidase activity |
| MF | IDA | GO:0016532 | superoxide dismutase copper chaperone activity |
| MF | IDA | GO:0016684 | oxidoreductase activity, acting on peroxide as acceptor |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IPI | GO:0019955 | cytokine binding |
| MF | IDA | GO:0036470 | tyrosine 3-monooxygenase activator activity |
| MF | IDA | GO:0036478 | L-dopa decarboxylase activator activity |
| MF | IBA | GO:0036524 | protein deglycase activity |
| MF | IDA | GO:0036524 | protein deglycase activity |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | IPI | GO:0044388 | small protein activating enzyme binding |
| MF | IPI | GO:0044390 | ubiquitin-like protein conjugating enzyme binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IDA | GO:0045340 | mercury ion binding |
| MF | IPI | GO:0050681 | androgen receptor binding |
| MF | IEA | GO:0051920 | peroxiredoxin activity |
| MF | IPI | GO:0070491 | repressing transcription factor binding |
| MF | IPI | GO:0097110 | scaffold protein binding |
| MF | IDA | GO:1903135 | cupric ion binding |
| MF | IDA | GO:1903136 | cuprous ion binding |
| MF | IPI | GO:1990381 | ubiquitin-specific protease binding |
Gene expression in normal tissue: PARK7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PARK7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3899300 | SUMOylation of transcription cofactors |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-597592 | Post-translational protein modification |
| wikipathways | WP138 | Androgen receptor signaling pathway |
| wikipathways | WP2267 | Synaptic Vesicle Pathway |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| pid | alphasynuclein_pathway | Alpha-synuclein signaling |
| kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD33 | Entinostat | 1 |
| iGMDRD798 | Ceranib-2 | 1 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD256 | NVP-231 | 1 |
| iGMDRD646 | PHA-793887 | 1 |
| iGMDRD106 | Clofarabine | 1 |
| iGMDRD552 | AZD-1775 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PARK7
CLASSFICATION
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