iGMDRD120

Canonical SMILES: C1CN(CCC1CC(=O)N2CCC(CC2)C3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N

InChI: InChI=1S/C27H31Br2ClN4O2/c28-20-12-19-2-1-18-13-21(30)14-22(29)24(18)25(26(19)32-15-20)17-5-9-33(10-6-17)23(35)11-16-3-7-34(8-4-16)27(31)36/h12-17,25H,1-11H2,(H2,31,36)/t25-/m1/s1

InChI Key: DHMTURDWPRKSOA-RUZDIDTESA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameLonafarnib
CHEMBLCHEMBL298734
Pubchem CID148195
DRUGBANK IDDB06448
Drug StatusAlone
Drug TypeSmall Molecule


Drug-model tissue-cancer distribution: Bubble Plot

OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: Ovarian Cancer model num: 1

Drug-gene pathway enrichments

1reactome: GPCR downstream signalling1reactome: G alpha (i) signalling events1kegg: Terpenoid backbone biosynthesis - Homo sapiens (human)1reactome: Signaling by GPCR1reactome: Inactivation, recovery and regulation of the phototransduction cascade1reactome: Visual phototransduction1reactome: The phototransduction cascade1reactome: Signal Transduction

Drug-gene GO enrichments

3MF: protein farnesyltransferase activity2CC: protein farnesyltransferase complex2BP: protein farnesylation1MF: farnesyltranstransferase activity1MF: protein binding1MF: prenyltransferase activity1MF: drug binding1MF: peptide binding1MF: isoprenoid binding1MF: zinc ion binding

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2342 FNTB 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Models in Lonafarnib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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