iGMDRD168

Canonical SMILES: CC1(CCC(C2=C1C=CC(=C2)C(C(=O)NC3=C(C=C(C=C3)C(=O)O)F)O)(C)C)C

InChI: InChI=1S/C23H26FNO4/c1-22(2)9-10-23(3,4)16-11-13(5-7-15(16)22)19(26)20(27)25-18-8-6-14(21(28)29)12-17(18)24/h5-8,11-12,19,26H,9-10H2,1-4H3,(H,25,27)(H,28,29)/t19-/m1/s1

InChI Key: AANFHDFOMFRLLR-LJQANCHMSA-N

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Standard Name
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameBMS-270394
Pubchem CID445455
DRUGBANK IDDB07031
Drug StatusAlone
Drug TypeSmall Molecule


Drug Targets:

RARG (P13631)

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

2reactome: Innate Immune System2reactome: Signal Transduction2reactome: Signaling by SCF-KIT2reactome: Immune System2reactome: DAP12 interactions2reactome: DAP12 signaling2reactome: Signaling by Receptor Tyrosine Kinases1pid: Atypical NF-kappaB pathway1pid: IL2 signaling events mediated by STAT51pid: Regulation of p38-alpha and p38-beta

Drug-gene GO enrichments

5MF: protein tyrosine kinase activity3BP: T cell differentiation2MF: SH2 domain binding2CC: plasma membrane2CC: pericentriolar material2BP: response to drug2CC: membrane raft2BP: positive regulation of T cell activation2MF: protein serine/threonine phosphatase activity2BP: positive regulation of intrinsic apoptotic signaling pathway

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3932 LCK 1
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Gene in drug-gene network: Network Plot

Models in BMS-270394

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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