iGMDRD216

Canonical SMILES: C1=NC2=C(N1)C(=S)N=C(N2)N

InChI: InChI=1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

InChI Key: WYWHKKSPHMUBEB-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
KEGG Drug ID
DRUGBANK ID
Drug Status
Drug targets (TTD)
Drug Type
Standard Name6-Thioguanine
CHEMBLCHEMBL727
Pubchem CID2723600
KEGG Drug IDD08603
DRUGBANK IDDB00352
Drug StatusAlone
Drug targets (TTD)DAP000194
Drug TypeSmall Molecule


Drug Targets:

DNA

Drug Pathways:

Purine metabolism

Drug-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: T-Cell Acute Lymphoid Leukemia (TALL) model num: 3

Drug-gene pathway enrichments

1smpdb: Xanthinuria type I1smpdb: Xanthinuria type II1smpdb: Adenine phosphoribosyltransferase deficiency (APRT)1smpdb: Thioguanine Action Pathway1smpdb: Mercaptopurine Action Pathway1smpdb: Lesch-Nyhan Syndrome (LNS)1smpdb: Gout or Kelley-Seegmiller Syndrome1smpdb: Azathioprine Action Pathway1smpdb: Mitochondrial DNA depletion syndrome1smpdb: Myoadenylate deaminase deficiency

Drug-gene GO enrichments

2MF: 5'-nucleotidase activity1BP: drug metabolic process1BP: IMP metabolic process1BP: adenosine metabolic process1BP: dephosphorylation1CC: cytosol1BP: purine nucleotide catabolic process1MF: protein binding1MF: metal ion binding1MF: nucleoside phosphotransferase activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
22978 NT5C2 3
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Gene in drug-gene network: Network Plot

NelarabineNelarabine6-mercaptopurine6-mercaptopurineArabinosylguanineArabinosylguanineNT5C2NT5C26-thioguanine6-thioguanine

Models in 6-Thioguanine

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
SNV(NT5C2 R367Q) gene 23377281 BLOOD T-Cell Acute Lymphoid Leukemia (TALL) 6-thioguanine resistance or unresponsive in vivo
SNV(NT5C2 K359Q) gene 23377281 BLOOD T-Cell Acute Lymphoid Leukemia (TALL) 6-thioguanine resistance or unresponsive in vivo
SNV(NT5C2 D407A) gene 23377281 BLOOD T-Cell Acute Lymphoid Leukemia (TALL) 6-thioguanine resistance or unresponsive in vivo
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