NT5C2
Summary: This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| 5'-nucleotidase, cytosolic II | MIM:600417 | Ensembl:ENSG00000076685 | HGNC:HGNC:8022 | PA31801 | 10q24.32-q24.33 |
GO terms in NT5C2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0000166 | nucleotide binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | EXP | GO:0008253 | 5'-nucleotidase activity |
| MF | IBA | GO:0008253 | 5'-nucleotidase activity |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | TAS | GO:0050146 | nucleoside phosphotransferase activity |
| BP | TAS | GO:0006195 | purine nucleotide catabolic process |
| BP | IEA | GO:0016310 | phosphorylation |
| BP | IEA | GO:0016311 | dephosphorylation |
| BP | TAS | GO:0017144 | drug metabolic process |
| BP | IBA | GO:0046040 | IMP metabolic process |
| BP | IBA | GO:0046085 | adenosine metabolic process |
| CC | TAS | GO:0005829 | cytosol |
Gene expression in normal tissue: NT5C2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NT5C2
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-15869 | Metabolism of nucleotides |
| reactome | R-HSA-2161522 | Abacavir transport and metabolism |
| reactome | R-HSA-2161541 | Abacavir metabolism |
| reactome | R-HSA-74259 | Purine catabolism |
| reactome | R-HSA-8956319 | Nucleobase catabolism |
| smpdb | SMP00046 | Pyrimidine Metabolism |
| smpdb | SMP00048 | Nicotinate and Nicotinamide Metabolism |
| smpdb | SMP00050 | Purine Metabolism |
| smpdb | SMP00144 | Adenosine Deaminase Deficiency |
| smpdb | SMP00167 | Adenylosuccinate Lyase Deficiency |
| smpdb | SMP00168 | AICA-Ribosiduria |
| smpdb | SMP00172 | Beta Ureidopropionase Deficiency |
| smpdb | SMP00178 | Dihydropyrimidinase Deficiency |
| smpdb | SMP00202 | MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy) |
| smpdb | SMP00203 | Molybdenum Cofactor Deficiency |
| smpdb | SMP00210 | Purine Nucleoside Phosphorylase Deficiency |
| smpdb | SMP00219 | UMP Synthase Deiciency (Orotic Aciduria) |
| smpdb | SMP00220 | Xanthine Dehydrogenase Deficiency (Xanthinuria) |
| smpdb | SMP00364 | Lesch-Nyhan Syndrome (LNS) |
| smpdb | SMP00365 | Gout or Kelley-Seegmiller Syndrome |
| smpdb | SMP00427 | Azathioprine Action Pathway |
| smpdb | SMP00428 | Mercaptopurine Action Pathway |
| smpdb | SMP00430 | Thioguanine Action Pathway |
| smpdb | SMP00512 | Xanthinuria type I |
| smpdb | SMP00513 | Xanthinuria type II |
| smpdb | SMP00535 | Adenine phosphoribosyltransferase deficiency (APRT) |
| smpdb | SMP00536 | Mitochondrial DNA depletion syndrome |
| smpdb | SMP00537 | Myoadenylate deaminase deficiency |
| kegg | hsa00230 | Purine metabolism - Homo sapiens (human) |
| kegg | hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| kegg | hsa00760 | Nicotinate and nicotinamide metabolism - Homo sapiens (human) |
| humancyc | PWY-5695 | urate biosynthesis/inosine 5,-phosphate degradation |
| humancyc | PWY-6353 | purine nucleotides degradation |
| humancyc | PWY-6608 | guanosine nucleotides degradation |
| humancyc | SALVADEHYPOX-PWY | adenosine nucleotides degradation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD216 | 6-Thioguanine | 3 |
| iGMDRD194 | 6-Mercaptopurine | 3 |
| iGMDRD233 | Nelarabine | 3 |
| iGMDRD89 | Arabinosylguanine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NT5C2
CLASSFICATION
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