NT5C2


Summary: This gene encodes a hydrolase that serves as an important role in cellular purine metabolism by acting primarily on inosine 5'-monophosphate and other purine nucleotides. [provided by RefSeq, Oct 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
5'-nucleotidase, cytosolic IIMIM:600417Ensembl:ENSG00000076685HGNC:HGNC:8022PA3180110q24.32-q24.33

Gene Categories:

KINASEDRUG METABOLISM

GO terms in NT5C2


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000166nucleotide binding
MFIPIGO:0005515protein binding
MFEXPGO:00082535'-nucleotidase activity
MFIBAGO:00082535'-nucleotidase activity
MFIEAGO:0046872metal ion binding
MFTASGO:0050146nucleoside phosphotransferase activity
BPTASGO:0006195purine nucleotide catabolic process
BPIEAGO:0016310phosphorylation
BPIEAGO:0016311dephosphorylation
BPTASGO:0017144drug metabolic process
BPIBAGO:0046040IMP metabolic process
BPIBAGO:0046085adenosine metabolic process
CCTASGO:0005829cytosol

Gene expression in normal tissue: NT5C2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NT5C2


DatabasePathway IDPathway Des.
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-15869Metabolism of nucleotides
reactomeR-HSA-2161522Abacavir transport and metabolism
reactomeR-HSA-2161541Abacavir metabolism
reactomeR-HSA-74259Purine catabolism
reactomeR-HSA-8956319Nucleobase catabolism
smpdbSMP00046Pyrimidine Metabolism
smpdbSMP00048Nicotinate and Nicotinamide Metabolism
smpdbSMP00050Purine Metabolism
smpdbSMP00144Adenosine Deaminase Deficiency
smpdbSMP00167Adenylosuccinate Lyase Deficiency
smpdbSMP00168AICA-Ribosiduria
smpdbSMP00172Beta Ureidopropionase Deficiency
smpdbSMP00178Dihydropyrimidinase Deficiency
smpdbSMP00202MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)
smpdbSMP00203Molybdenum Cofactor Deficiency
smpdbSMP00210Purine Nucleoside Phosphorylase Deficiency
smpdbSMP00219UMP Synthase Deiciency (Orotic Aciduria)
smpdbSMP00220Xanthine Dehydrogenase Deficiency (Xanthinuria)
smpdbSMP00364Lesch-Nyhan Syndrome (LNS)
smpdbSMP00365Gout or Kelley-Seegmiller Syndrome
smpdbSMP00427Azathioprine Action Pathway
smpdbSMP00428Mercaptopurine Action Pathway
smpdbSMP00430Thioguanine Action Pathway
smpdbSMP00512Xanthinuria type I
smpdbSMP00513Xanthinuria type II
smpdbSMP00535Adenine phosphoribosyltransferase deficiency (APRT)
smpdbSMP00536Mitochondrial DNA depletion syndrome
smpdbSMP00537Myoadenylate deaminase deficiency
kegghsa00230Purine metabolism - Homo sapiens (human)
kegghsa00240Pyrimidine metabolism - Homo sapiens (human)
kegghsa00760Nicotinate and nicotinamide metabolism - Homo sapiens (human)
humancycPWY-5695urate biosynthesis/inosine 5,-phosphate degradation
humancycPWY-6353purine nucleotides degradation
humancycPWY-6608guanosine nucleotides degradation
humancycSALVADEHYPOX-PWYadenosine nucleotides degradation

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD2166-Thioguanine3
iGMDRD1946-Mercaptopurine3
iGMDRD233Nelarabine3
iGMDRD89Arabinosylguanine3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NT5C2

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