iGMDRD89

Canonical SMILES: C1=NC2=C(N1C3C(C(C(O3)CO)O)O)NC(=NC2=O)N

InChI: InChI=1S/C10H13N5O5/c11-10-13-7-4(8(19)14-10)12-2-15(7)9-6(18)5(17)3(1-16)20-9/h2-3,5-6,9,16-18H,1H2,(H3,11,13,14,19)/t3-,5-,6+,9-/m1/s1

InChI Key: NYHBQMYGNKIUIF-FJFJXFQQSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameArabinosylguanine
CHEMBLCHEMBL240933
Pubchem CID65412
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: T-Cell Acute Lymphoid Leukemia (TALL) model num: 3

Drug-gene pathway enrichments

1smpdb: Xanthinuria type I1smpdb: Xanthinuria type II1smpdb: Adenine phosphoribosyltransferase deficiency (APRT)1smpdb: Thioguanine Action Pathway1smpdb: Mercaptopurine Action Pathway1smpdb: Lesch-Nyhan Syndrome (LNS)1smpdb: Gout or Kelley-Seegmiller Syndrome1smpdb: Azathioprine Action Pathway1smpdb: Mitochondrial DNA depletion syndrome1smpdb: Myoadenylate deaminase deficiency

Drug-gene GO enrichments

2MF: 5'-nucleotidase activity1BP: drug metabolic process1BP: IMP metabolic process1BP: adenosine metabolic process1BP: dephosphorylation1CC: cytosol1BP: purine nucleotide catabolic process1MF: protein binding1MF: metal ion binding1MF: nucleoside phosphotransferase activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
22978 NT5C2 3
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Gene in drug-gene network: Network Plot

NelarabineNelarabine6-thioguanine6-thioguanine6-mercaptopurine6-mercaptopurineNT5C2NT5C2ArabinosylguanineArabinosylguanine

Models in Arabinosylguanine

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
SNV(NT5C2 R367Q) gene 23377281 BLOOD T-Cell Acute Lymphoid Leukemia (TALL) Arabinosylguanine resistance or unresponsive in vivo
SNV(NT5C2 D407A) gene 23377281 BLOOD T-Cell Acute Lymphoid Leukemia (TALL) Arabinosylguanine resistance or unresponsive in vivo
SNV(NT5C2 K359Q) gene 23377281 BLOOD T-Cell Acute Lymphoid Leukemia (TALL) Arabinosylguanine resistance or unresponsive in vivo
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