iGMDRD234

Canonical SMILES: C1=C(SC=C1Br)COC2=NC(=NC3=C2NC=N3)N

InChI: InChI=1S/C10H8BrN5OS/c11-5-1-6(18-3-5)2-17-9-7-8(14-4-13-7)15-10(12)16-9/h1,3-4H,2H2,(H3,12,13,14,15,16)

InChI Key: JUJPKFNFCWJBCX-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameLomeguatrib
Pubchem CID3025940
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

MGMT

Drug-model tissue-cancer distribution: Bubble Plot

PANCREAtissue: PANCREA cancer: PANCREAS model num: 0PANCREAStissue: PANCREAS cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 6

Drug-gene pathway enrichments

2reactome: GPVI-mediated activation cascade2reactome: Hemostasis2reactome: Platelet activation, signaling and aggregation1pid: Insulin Pathway1pid: Signaling events mediated by Stem cell factor receptor (c-Kit)1pid: Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)1pid: mTOR signaling pathway1pid: IL8- and CXCR2-mediated signaling events1pid: IL8- and CXCR1-mediated signaling events1pid: FAS (CD95) signaling pathway

Drug-gene GO enrichments

4MF: protein serine/threonine kinase activity3CC: nucleoplasm3CC: cytoplasm2CC: nucleus2BP: positive regulation of transcription by RNA polymerase II2BP: intracellular signal transduction2BP: activation of protein kinase B activity2BP: double-strand break repair via nonhomologous end joining2MF: protein binding2BP: positive regulation of isotype switching

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
7158 TP53BP1 1
5170 PDPK1 1
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Models in Lomeguatrib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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