iGMDRD337

Canonical SMILES: C1=CC=C(C(=C1)C(=C(N)SC2=CC=C(C=C2)N)C#N)C(F)(F)F

InChI: InChI=1S/C16H12F3N3S/c17-16(18,19)14-4-2-1-3-12(14)13(9-20)15(22)23-11-7-5-10(21)6-8-11/h1-8H,21-22H2/b15-13+

InChI Key: JLOXTZFYJNCPIS-FYWRMAATSA-N

Loading, please wait...
Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameMEK Inhibitor in BRAF mutant tumors
CHEMBLCHEMBL261237
Pubchem CID9549280
Drug StatusFamily
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Melanoma (MEL) model num: 1

Drug-gene pathway enrichments

1reactome: RNA Polymerase II Transcription1reactome: Gene expression (Transcription)1reactome: PTEN Regulation1reactome: Post-translational protein modification1reactome: Ovarian tumor domain proteases1reactome: Regulation of PTEN mRNA translation1reactome: Regulation of PTEN localization1kegg: FoxO signaling pathway - Homo sapiens (human)1kegg: Phosphatidylinositol signaling system - Homo sapiens (human)1kegg: Inositol phosphate metabolism - Homo sapiens (human)

Drug-gene GO enrichments

2BP: negative regulation of phosphatidylinositol 3-kinase signaling2BP: negative regulation of cell proliferation2CC: cytosol2CC: nucleoplasm2BP: negative regulation of protein kinase B signaling2BP: phosphatidylinositol dephosphorylation2MF: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity2CC: cytoplasm2BP: negative regulation of protein phosphorylation2BP: protein dephosphorylation

Drug-Gene: Aster Plot


Loading, please wait...
Gene ID
Gene Name
Model Num.
5728 PTEN 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Models in MEK Inhibitor in BRAF mutant tumors

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.