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iGMDRD349

Canonical SMILES: COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl

InChI: InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)

InChI Key: WOSKHXYHFSIKNG-UHFFFAOYSA-N

Standard Name	CHEMBL	Pubchem CID	DRUGBANK ID	Drug Status	Drug Type
Lenvatinib	CHEMBL1289601	9823820	DB09078	Alone	Small Molecule

Drug Class:

Antineoplastic Agents Antineoplastic and Immunomodulating Agents BCRP/ABCG2 Substrates Benzene Derivatives Enzyme Inhibitors Heterocyclic Compounds Heterocyclic Compounds, 2-Ring Hydrocarbons Hydrocarbons, Aromatic Hydrocarbons, Cyclic Kinase Inhibitor Moderate Risk QTc-Prolonging Agents P-glycoprotein/ABCB1 Substrates Protein Kinase Inhibitors QTc Prolonging Agents Urea

Drug Targets:

FLT1 (P17948)KDR (P35968)FLT4 (P35916)FGFR1 (P11362)FGFR2 (P21802)FGFR3 (P22607)FGFR4 (P22455)Platelet derived growth factor receptor alpha RET KIT (P10721)FLT3 PDGFRA PDGFRB

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

Drug-gene GO enrichments

Drug-Gene: Aster Plot

Gene ID	Gene Name	Model Num.
5159	PDGFRB	1
2065	ERBB3	1

Gene in drug-gene network: Network Plot

Models in Lenvatinib

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DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.