iGMDRD355

Canonical SMILES: CCCN1C2=C(C(=O)N(C1=O)CCC)NC(=N2)C34CC5CC(C3)CC4C5.C1=COC(=C1)CNC2=CC(=C(C=C2C(=O)O)S(=O)(=O)N)Cl

InChI: InChI=1S/C20H28N4O2.C12H11ClN2O5S/c1-3-5-23-16-15(17(25)24(6-4-2)19(23)26)21-18(22-16)20-10-12-7-13(11-20)9-14(20)8-12;13-9-5-10(15-6-7-2-1-3-20-7)8(12(16)17)4-11(9)21(14,18)19/h12-14H,3-11H2,1-2H3,(H,21,22);1-5,15H,6H2,(H,16,17)(H2,14,18,19)

InChI Key: LLLIKHLUUMWXPN-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameConatumumab
Pubchem CID9831420
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BONtissue: BON cancer: BONE model num: 0BONEtissue: BONE cancer: Ewing Sarcoma (ES) model num: 1

Drug-gene pathway enrichments

1pid: Caspase Cascade in Apoptosis1pid: Ceramide signaling pathway1pid: Integrins in angiogenesis1pid: Coregulation of Androgen receptor activity1wikipathways: Toll-like Receptor Signaling Pathway1pid: FAS (CD95) signaling pathway1pid: HIV-1 Nef: Negative effector of Fas and TNF-alpha1netpath: RAGE1netpath: AndrogenReceptor1pid: TRAIL signaling pathway

Drug-gene GO enrichments

3BP: execution phase of apoptosis3BP: apoptotic process2MF: cysteine-type endopeptidase activity involved in apoptotic process2MF: cysteine-type endopeptidase activity involved in apoptotic signaling pathway2BP: apoptotic signaling pathway2BP: macrophage differentiation2BP: activation of cysteine-type endopeptidase activity involved in apoptotic process2CC: cytosol2BP: positive regulation of I-kappaB kinase/NF-kappaB signaling2MF: cysteine-type endopeptidase activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
841 CASP8 1
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Gene in drug-gene network: Network Plot

BMS-536924BMS-536924navitoclaxnavitoclaxcytochalasin.Bcytochalasin.BparbendazoleparbendazoleSB225002SB225002BRD4770BRD4770piperlonguminepiperlongumine179324-69-7179324-69-7GemcitabineGemcitabineCASP8CASP8ConatumumabConatumumab

Models in Conatumumab

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(CASP8) gene 26291055 BONE Ewing Sarcoma (ES) Conatumumab sensitivity in vivo
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