iGMDRD406

Canonical SMILES: CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO

InChI: InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)

InChI Key: ACWZRVQXLIRSDF-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameBinimetinib
CHEMBLCHEMBL3187723
Pubchem CID10288200
DRUGBANK IDDB11967
Drug StatusAlone
Drug TypeSmall Molecule

Drug Class:

UGT1A1 Substrates

Drug-model tissue-cancer distribution: Bubble Plot

OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 1BRAItissue: BRAI cancer: BRAIN model num: 0BRAINtissue: BRAIN cancer: Neuroblastoma (NBL) model num: 1SKItissue: SKI cancer: SKIN model num: 0SKINtissue: SKIN cancer: Melanoma (MEL) model num: 9PNtissue: PN cancer: PNS model num: 0PNStissue: PNS cancer: Neurofibroma (NFIB) model num: 2

Drug-gene pathway enrichments

5reactome: Signal Transduction4reactome: GRB2 events in ERBB2 signaling4reactome: Signalling to RAS4reactome: Signaling by Receptor Tyrosine Kinases4reactome: Signaling by ERBB24reactome: p38MAPK events4reactome: Signaling by NTRKs4reactome: Signalling to ERKs4reactome: Signaling by NTRK1 (TRKA)3reactome: MAPK1/MAPK3 signaling

Drug-gene GO enrichments

4BP: Ras protein signal transduction4BP: MAPK cascade4BP: positive regulation of GTPase activity3MF: protein binding3MF: GTPase activity3CC: plasma membrane3MF: GTP binding2CC: membrane2CC: cytoplasm2BP: positive regulation of endothelial cell proliferation

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4893 NRAS 10
4763 NF1 2
3265 HRAS 1
Showing 1 to 3 of 3 rows

Gene in drug-gene network: Network Plot

Models in Binimetinib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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