iGMDRD457
Standard Name | CHEMBL | Pubchem CID | DRUGBANK ID | Drug Status | Drug Type |
---|---|---|---|---|---|
Crizotinib and vemurafenib (in BRAF V600E mutated) | CHEMBL601719 | 11626600 | DB08865 | Combination | Small Molecule |
Drug Class:
Antineoplastic AgentsAntineoplastic and Immunomodulating AgentsAzolesBradycardia-Causing AgentsCombined Inhibitors of CYP3A4 and P-glycoproteinCombined Inhibitors of CYP3A4 and P-glycoprotein (Moderate)Cytochrome P-450 CYP3A InhibitorsCytochrome P-450 CYP3A4 InhibitorsCytochrome P-450 CYP3A4 Inhibitors (moderate)Cytochrome P-450 Enzyme InhibitorsEnzyme InhibitorsHeterocyclic CompoundsHeterocyclic Compounds, 1-RingKinase InhibitorModerate Risk QTc-Prolonging AgentsP-glycoprotein/ABCB1 InhibitorsP-glycoprotein/ABCB1 SubstratesProtein Kinase InhibitorsQTc Prolonging AgentsDrug-model tissue-cancer distribution: Bubble Plot
Drug-gene pathway enrichments
Drug-gene GO enrichments
Gene in drug-gene network: Network Plot
![](image/drug_network_legends.png)
Models in Crizotinib and vemurafenib (in BRAF V600E mutated)