iGMDRD471

Canonical SMILES: CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5

InChI: InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)

InChI Key: LIRYPHYGHXZJBZ-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameTrametinib (plus imatinib in BCR-ABL)
CHEMBLCHEMBL2105741 CHEMBL2103875
Pubchem CID11707100
DRUGBANK IDDB08911
Drug StatusCombination
Drug TypeSmall Molecule



Drug Pathways:

ERK MAPK signaling

Drug-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: Chronic Myelogenous Leukemia (CML) model num: 1

Drug-gene pathway enrichments

2reactome: GPCR downstream signalling2reactome: Signal Transduction2reactome: Signaling by GPCR1wikipathways: Signaling Pathways in Glioblastoma1wikipathways: miRs in Muscle Cell Differentiation1pharmgkb: VEGF Signaling Pathway1pharmgkb: Beta-agonist/Beta-blocker Pathway, Pharmacodynamics1wikipathways: Oncostatin M Signaling Pathway1wikipathways: Wnt Signaling Pathway and Pluripotency1wikipathways: Calcium Regulation in the Cardiac Cell

Drug-gene GO enrichments

2CC: cytosol1MF: protein serine/threonine kinase activity1CC: extracellular exosome1CC: plasma membrane1MF: protein kinase C activity1CC: cell-cell junction1MF: calcium-independent protein kinase C activity1MF: enzyme binding1MF: metal ion binding1MF: Ral GTPase binding

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5583 PRKCH 1
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Gene in drug-gene network: Network Plot

Models in Trametinib (plus imatinib in BCR-ABL)

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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