iGMDRD501

Canonical SMILES: C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4

InChI: InChI=1S/C18H21F3N6O2/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27/h9-11H,1-8H2,(H2,22,23)

InChI Key: CWHUFRVAEUJCEF-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameBuparlisib
CHEMBLCHEMBL2364604 CHEMBL2017974
Pubchem CID16655000
DRUGBANK IDDB11666
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 1

Drug-gene pathway enrichments

1reactome: RNA Polymerase II Transcription1reactome: Gene expression (Transcription)1reactome: PTEN Regulation1reactome: Post-translational protein modification1reactome: Ovarian tumor domain proteases1reactome: Regulation of PTEN mRNA translation1reactome: Regulation of PTEN localization1kegg: FoxO signaling pathway - Homo sapiens (human)1kegg: Phosphatidylinositol signaling system - Homo sapiens (human)1kegg: Inositol phosphate metabolism - Homo sapiens (human)

Drug-gene GO enrichments

2BP: negative regulation of phosphatidylinositol 3-kinase signaling2BP: negative regulation of cell proliferation2CC: cytosol2CC: nucleoplasm2BP: negative regulation of protein kinase B signaling2BP: phosphatidylinositol dephosphorylation2MF: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity2CC: cytoplasm2BP: negative regulation of protein phosphorylation2BP: protein dephosphorylation

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5728 PTEN 1
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Gene in drug-gene network: Network Plot

Models in Buparlisib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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