iGMDRD515


Canonical SMILES: CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)N(C)C(=O)C9=CC=CC=C9)OC

InChI: InChI=1S/C35H30N4O4/c1-35-32(42-3)25(37(2)34(41)19-11-5-4-6-12-19)17-26(43-35)38-23-15-9-7-13-20(23)28-29-22(18-36-33(29)40)27-21-14-8-10-16-24(21)39(35)31(27)30(28)38/h4-16,25-26,32H,17-18H2,1-3H3,(H,36,40)

InChI Key: BMGQWWVMWDBQGC-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameStaurosporine
Pubchem CID16760600
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

PKCPPKFLT1c-FGRothers

Drug-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: Acute Myeloid Leukemia (AML) model num: 2

Drug-gene pathway enrichments

1kegg: Ras signaling pathway - Homo sapiens (human)1kegg: Cytokine-cytokine receptor interaction - Homo sapiens (human)1kegg: MAPK signaling pathway - Homo sapiens (human)1wikipathways: Ras Signaling1wikipathways: Wnt-beta-catenin Signaling Pathway in Leukemia1wikipathways: PI3K-Akt Signaling Pathway1kegg: PI3K-Akt signaling pathway - Homo sapiens (human)1kegg: Hematopoietic cell lineage - Homo sapiens (human)1pharmgkb: Pathway_PA1659594251pharmgkb: Sorafenib Pharmacodynamics

Drug-gene GO enrichments

2BP: positive regulation of MAPK cascade2CC: integral component of plasma membrane2BP: cellular response to cytokine stimulus2BP: cytokine-mediated signaling pathway2MF: transmembrane receptor protein tyrosine kinase activity1BP: cell differentiation1BP: B cell differentiation1BP: animal organ regeneration1BP: positive regulation of kinase activity1BP: negative regulation of signal transduction

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2322 FLT3 2
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Gene in drug-gene network: Network Plot

Models in Staurosporine

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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