iGMDRD531

Canonical SMILES: C1CC1C(=O)N2CCN(CC2)C(=O)C3=C(C=CC(=C3)CC4=NNC(=O)C5=CC=CC=C54)F

InChI: InChI=1S/C24H23FN4O3/c25-20-8-5-15(14-21-17-3-1-2-4-18(17)22(30)27-26-21)13-19(20)24(32)29-11-9-28(10-12-29)23(31)16-6-7-16/h1-5,8,13,16H,6-7,9-12,14H2,(H,27,30)

InChI Key: FDLYAMZZIXQODN-UHFFFAOYSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameAZD2281
Pubchem CID23725600
Drug StatusAlone
Drug TypeSmall Molecule

Drug Targets:

PARP1PARP2

Drug Pathways:

Genome integrity

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 5BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 1UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: undefined model num: 1

Drug-gene pathway enrichments

2reactome: Signaling by TGF-beta family members2reactome: Generic Transcription Pathway2reactome: Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer2reactome: Downregulation of SMAD2/3:SMAD4 transcriptional activity2reactome: RNA Polymerase II Transcription2reactome: Gene expression (Transcription)2reactome: Signaling by TGF-beta Receptor Complex2wikipathways: Mesodermal Commitment Pathway2reactome: Signaling by NODAL2reactome: Signal Transduction

Drug-gene GO enrichments

3BP: negative regulation of transcription by RNA polymerase II3MF: histone-lysine N-methyltransferase activity3CC: nucleoplasm3BP: positive regulation of transcription by RNA polymerase II3MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding2BP: embryonic cranial skeleton morphogenesis2BP: positive regulation of epithelial to mesenchymal transition2CC: nucleus2BP: pericardium development2BP: histone H3-K36 trimethylation

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4088 SMAD3 1
29072 SETD2 1
Showing 1 to 2 of 2 rows

Gene in drug-gene network: Network Plot

Models in AZD2281

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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