iGMDRD603


Canonical SMILES: C1=CC(=C(C=C1I)F)NC2=C(C=CC3=CN=CN32)C(=O)NOCCO

InChI: InChI=1S/C16H14FIN4O3/c17-13-7-10(18)1-4-14(13)20-15-12(16(24)21-25-6-5-23)3-2-11-8-19-9-22(11)15/h1-4,7-9,20,23H,5-6H2,(H,21,24)

InChI Key: RFWVETIZUQEJEF-UHFFFAOYSA-N

Loading, please wait...
Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameGDC-0623
Pubchem CID42642700
DRUGBANK IDDB11982
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 1

Drug-gene pathway enrichments

2reactome: Signal Transduction2reactome: GRB2 events in ERBB2 signaling2reactome: Signaling by ERBB22reactome: p38MAPK events2reactome: Signaling by NTRK1 (TRKA)2reactome: Signalling to ERKs2reactome: Signaling by Receptor Tyrosine Kinases2reactome: Signalling to RAS2reactome: Signaling by NTRKs1reactome: Signaling by RAS mutants

Drug-gene GO enrichments

1CC: cytoplasm1CC: mitochondrion1CC: cytosol1CC: plasma membrane1BP: positive regulation of cellular senescence1BP: epithelial tube branching involved in lung morphogenesis1BP: positive regulation of NF-kappaB transcription factor activity1BP: striated muscle cell differentiation1BP: response to glucocorticoid1BP: response to mineralocorticoid

Drug-Gene: Aster Plot


Loading, please wait...
Gene ID
Gene Name
Model Num.
3845 KRAS 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Models in GDC-0623

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​