iGMDRD637

Canonical SMILES: C[C@H](CO)N1C[C@H](C)[C@@H](CN(C)C(=O)Nc2cccc3ccccc23)Oc4ccc(NC(=O)c5ccncc5)cc4CC1=O

InChI: InChI=1S/C34H37N5O5/c1-22-19-39(23(2)21-40)32(41)18-26-17-27(36-33(42)25-13-15-35-16-14-25)11-12-30(26)44-31(22)20-38(3)34(43)37-29-10-6-8-24-7-4-5-9-28(24)29/h4-17,22-23,31,40H,18-21H2,1-3H3,(H,36,42)(H,37,43)/t22-,23+,31+/m0/s1

InChI Key: LDEMJBAJJXLTPL-INEJIFKHSA-N

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Standard Name
Pubchem CID
Drug Status
Standard NameBRD-K37390332
Pubchem CID44620200
Drug StatusAlone

Drug-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 1undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 1

Drug-gene pathway enrichments

1kegg: MicroRNAs in cancer - Homo sapiens (human)1kegg: Pathways in cancer - Homo sapiens (human)1kegg: HTLV-I infection - Homo sapiens (human)1kegg: Glioma - Homo sapiens (human)1kegg: Prostate cancer - Homo sapiens (human)1kegg: Central carbon metabolism in cancer - Homo sapiens (human)1kegg: Melanoma - Homo sapiens (human)1kegg: Human papillomavirus infection - Homo sapiens (human)1kegg: Regulation of actin cytoskeleton - Homo sapiens (human)1kegg: Phospholipase D signaling pathway - Homo sapiens (human)

Drug-gene GO enrichments

3MF: platelet-derived growth factor beta-receptor activity3MF: platelet-derived growth factor binding3BP: positive regulation of ERK1 and ERK2 cascade2BP: positive regulation of smooth muscle cell migration2CC: membrane2BP: negative regulation of apoptotic process2BP: positive regulation of smooth muscle cell proliferation2CC: cytoplasm2BP: positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway2MF: platelet-derived growth factor-activated receptor activity

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
5159 PDGFRB 1
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Gene in drug-gene network: Network Plot

Models in BRD-K37390332

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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