iGMDRD648

Canonical SMILES: C1=CC(=CC(=C1)F)NC(=O)NC2=CC=C(C=C2)C3=CSC4=C3C(=NC=C4C5=CN(N=C5)CCO)N

InChI: InChI=1S/C25H21FN6O2S/c26-17-2-1-3-19(10-17)31-25(34)30-18-6-4-15(5-7-18)21-14-35-23-20(12-28-24(27)22(21)23)16-11-29-32(13-16)8-9-33/h1-7,10-14,33H,8-9H2,(H2,27,28)(H2,30,31,34)

InChI Key: WPHKIQPVPYJNAX-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameILORASERTIB
CHEMBLCHEMBL1980297
Pubchem CID46207600
DRUGBANK IDDB11694
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 2

Drug-gene pathway enrichments

1pid: Regulation of nuclear beta catenin signaling and target gene transcription1pid: Coregulation of Androgen receptor activity1pid: AP-1 transcription factor network1wikipathways: DNA Damage Response (only ATM dependent)1pid: C-MYB transcription factor network1pid: Validated transcriptional targets of deltaNp63 isoforms1pid: Validated transcriptional targets of AP1 family members Fra1 and Fra21pid: FOXM1 transcription factor network1pid: E2F transcription factor network1wikipathways: Senescence and Autophagy in Cancer

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
1029 CDKN2A 2
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Gene in drug-gene network: Network Plot

Models in ILORASERTIB

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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