iGMDRD651

Canonical SMILES: CCCC(C(=O)NC1=CN(C=N1)C(C)(C)CNCC(C)(C)C)NC2CCC3=CC(=CC(=C3C2)F)F

InChI: InChI=1S/C27H41F2N5O/c1-7-8-23(32-20-10-9-18-11-19(28)12-22(29)21(18)13-20)25(35)33-24-14-34(17-31-24)27(5,6)16-30-15-26(2,3)4/h11-12,14,17,20,23,30,32H,7-10,13,15-16H2,1-6H3,(H,33,35)/t20-,23-/m0/s1

InChI Key: VFCRKLWBYMDAED-REWPJTCUSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NamePF-03084014
CHEMBLCHEMBL1770916
Pubchem CID46224400
DRUGBANK IDDB12005
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 4

Drug-gene pathway enrichments

3wikipathways: Notch Signaling Pathway2reactome: Pre-NOTCH Processing in Golgi2reactome: Pre-NOTCH Transcription and Translation2reactome: Generic Transcription Pathway2reactome: Pre-NOTCH Expression and Processing2reactome: Signaling by NOTCH12reactome: NOTCH1 Intracellular Domain Regulates Transcription2reactome: Activated NOTCH1 Transmits Signal to the Nucleus2reactome: Signaling by NOTCH2reactome: RNA Polymerase II Transcription

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4851 NOTCH1 4
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Gene in drug-gene network: Network Plot

Models in PF-03084014

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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