iGMDRD665

Canonical SMILES: CC(CONC(=O)C1=C(C2=CN=CC(=C2O1)F)NC3=C(C=C(C=C3)I)F)O

InChI: InChI=1S/C17H14F2IN3O4/c1-8(24)7-26-23-17(25)16-14(10-5-21-6-12(19)15(10)27-16)22-13-3-2-9(20)4-11(13)18/h2-6,8,22,24H,7H2,1H3,(H,23,25)/t8-/m0/s1

InChI Key: ZEZHPEIEEFTILY-QMMMGPOBSA-N

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Standard Name
Pubchem CID
Drug Status
Drug Type
Standard NameG-573
Pubchem CID46926400
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

OTHEtissue: OTHE cancer: OTHER model num: 0OTHERtissue: OTHER cancer: Cancer of Unknown Primary (CUP) model num: 1

Drug-gene pathway enrichments

2reactome: Signal Transduction2reactome: GRB2 events in ERBB2 signaling2reactome: Signaling by ERBB22reactome: p38MAPK events2reactome: Signaling by NTRK1 (TRKA)2reactome: Signalling to ERKs2reactome: Signaling by Receptor Tyrosine Kinases2reactome: Signalling to RAS2reactome: Signaling by NTRKs1reactome: Signaling by RAS mutants

Drug-gene GO enrichments

1CC: cytoplasm1CC: mitochondrion1CC: cytosol1CC: plasma membrane1BP: positive regulation of cellular senescence1BP: epithelial tube branching involved in lung morphogenesis1BP: positive regulation of NF-kappaB transcription factor activity1BP: striated muscle cell differentiation1BP: response to glucocorticoid1BP: response to mineralocorticoid

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
3845 KRAS 1
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Gene in drug-gene network: Network Plot

Models in G-573

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
MUT(KRAS) gene 23934108 OTHER Cancer of Unknown Primary (CUP) G-573 sensitivity in vivo
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