iGMDRD691

Canonical SMILES: CCN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(C)C(=O)NC4=C(C(=CC(=C4Cl)OC)OC)Cl

InChI: InChI=1S/C26H31Cl2N7O3/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31)

InChI Key: QADPYRIHXKWUSV-UHFFFAOYSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameInfigratinib
CHEMBLCHEMBL1834657 CHEMBL1852688
Pubchem CID53235500
DRUGBANK IDDB11886
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

HEAD_NECtissue: HEAD_NEC cancer: HEAD_NECK model num: 0HEAD_NECKtissue: HEAD_NECK cancer: Head and Neck Squamous Cell Carcinoma (HNSC) model num: 1STOMACtissue: STOMAC cancer: STOMACH model num: 0STOMACHtissue: STOMACH cancer: Esophagogastric Adenocarcinoma (EGC) model num: 1BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Cancer model num: 1BILIARY_TRACtissue: BILIARY_TRAC cancer: BILIARY_TRACT model num: 0BILIARY_TRACTtissue: BILIARY_TRACT cancer: Cholangiocarcinoma (CHOL) model num: 4LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: Non-Small Cell Lung Cancer (NSCLC) model num: 1

Drug-gene pathway enrichments

2reactome: Developmental Biology2reactome: Axon guidance1pid: FGF signaling pathway1wikipathways: Regulation of Actin Cytoskeleton1pid: Glypican 1 network1pid: Posttranslational regulation of adherens junction stability and dissassembly1pid: Syndecan-1-mediated signaling events1pid: Syndecan-3-mediated signaling events1pid: Syndecan-2-mediated signaling events1wikipathways: Endochondral Ossification

Drug-gene GO enrichments

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2260 FGFR1 4
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Gene in drug-gene network: Network Plot

Models in Infigratinib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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