iGMDRD702

Canonical SMILES: CC(C)(C)CC1C2(C(C(N1)C(=O)NC3CCC(CC3)O)C4=C(C(=CC=C4)Cl)F)C5=C(C=C(C=C5)Cl)NC2=O

InChI: InChI=1S/C29H34Cl2FN3O3/c1-28(2,3)14-22-29(19-12-7-15(30)13-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-16-8-10-17(36)11-9-16/h4-7,12-13,16-17,22-23,25,35-36H,8-11,14H2,1-3H3,(H,33,37)(H,34,38)/t16?,17?,22-,23-,25+,29+/m0/s1

InChI Key: IDKAKZRYYDCJDU-AEPXTFJPSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameSAR405838
CHEMBLCHEMBL2381408
Pubchem CID53476900
DRUGBANK IDDB12541
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

SOFT_TISSUtissue: SOFT_TISSU cancer: SOFT_TISSUE model num: 0SOFT_TISSUEtissue: SOFT_TISSUE cancer: Liposarcoma (LIPO) model num: 1

Drug-gene pathway enrichments

1kegg: Human papillomavirus infection - Homo sapiens (human)1kegg: Epstein-Barr virus infection - Homo sapiens (human)1kegg: Thyroid hormone signaling pathway - Homo sapiens (human)1kegg: C-type lectin receptor signaling pathway - Homo sapiens (human)1kegg: Cellular senescence - Homo sapiens (human)1kegg: Pathways in cancer - Homo sapiens (human)1kegg: Transcriptional misregulation in cancer - Homo sapiens (human)1kegg: Glioma - Homo sapiens (human)1kegg: Prostate cancer - Homo sapiens (human)1kegg: MicroRNAs in cancer - Homo sapiens (human)

Drug-gene GO enrichments

3MF: ubiquitin protein ligase activity3BP: ubiquitin-dependent protein catabolic process2BP: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest2CC: nucleoplasm2BP: negative regulation of transcription, DNA-templated2CC: nucleus2MF: ubiquitin-protein transferase activity2BP: protein destabilization2CC: protein-containing complex2CC: nucleolus

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
4193 MDM2 1
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Gene in drug-gene network: Network Plot

Models in SAR405838

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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