iGMDRD704

Canonical SMILES: CC(C)C1=CC(=C2NNC(=O)N2C3=CC4=C(C=C3)N(C=C4)C)C(=O)C=C1O

InChI: InChI=1S/C20H20N4O3/c1-11(2)14-9-15(18(26)10-17(14)25)19-21-22-20(27)24(19)13-4-5-16-12(8-13)6-7-23(16)3/h4-11,21,25H,1-3H3,(H,22,27)

InChI Key: MWTUOSWPJOUADP-UHFFFAOYSA-N

Loading, please wait...
Standard Name
CHEMBL
Pubchem CID
Drug Status
Drug Type
Standard NameGanetespib (STA-9090)
CHEMBLCHEMBL2103879
Pubchem CID53629900
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: Colorectal Cancer model num: 1

Drug-gene pathway enrichments

1smpdb: Morphine Action Pathway1smpdb: Vitamin A Deficiency1smpdb: Irinotecan Action Pathway1smpdb: Etoposide Action Pathway1smpdb: Irinotecan Metabolism Pathway1smpdb: Ibuprofen Metabolism Pathway1smpdb: Phenytoin (Antiarrhythmic) Action Pathway1smpdb: Ibuprofen Action Pathway1wikipathways: Estrogen metabolism1wikipathways: Liver steatosis AOP

Drug-gene GO enrichments

2BP: flavonoid glucuronidation2MF: glucuronosyltransferase activity2BP: cellular glucuronidation2BP: xenobiotic glucuronidation1CC: endoplasmic reticulum chaperone complex1CC: intracellular membrane-bounded organelle1CC: cytochrome complex1CC: integral component of plasma membrane1CC: endoplasmic reticulum membrane1BP: cellular response to estradiol stimulus

Drug-Gene: Aster Plot


Loading, please wait...
Gene ID
Gene Name
Model Num.
54658 UGT1A1 1
Showing 1 to 1 of 1 rows

Gene in drug-gene network: Network Plot

Models in Ganetespib (STA-9090)

Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
EXP(UGT1A) gene 25210794 BOWEL Colorectal Cancer Ganetespib resistance or unresponsive in vivo
Showing 1 to 1 of 1 rows

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.