iGMDRD731

Canonical SMILES: CCC(=C(C1=CC=C(C=C1)C=CC(=O)O)C2=CC3=C(C=C2)NN=C3)C4=C(C=C(C=C4)F)Cl

InChI: InChI=1S/C26H20ClFN2O2/c1-2-21(22-10-9-20(28)14-23(22)27)26(18-8-11-24-19(13-18)15-29-30-24)17-6-3-16(4-7-17)5-12-25(31)32/h3-15H,2H2,1H3,(H,29,30)(H,31,32)/b12-5+,26-21+

InChI Key: BURHGPHDEVGCEZ-KJGLQBJMSA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameGDC-0810
CHEMBLCHEMBL3581693
Pubchem CID56941200
DRUGBANK IDDB12253
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: Invasive Breast Carcinoma (BRCA) model num: 3BREASTtissue: BREAST cancer: Breast Carcinoma model num: 4

Drug-gene pathway enrichments

2reactome: Gene expression (Transcription)2reactome: Generic Transcription Pathway2reactome: Transcriptional regulation by RUNX22reactome: RNA Polymerase II Transcription2reactome: Regulation of RUNX2 expression and activity1wikipathways: Leptin signaling pathway1wikipathways: Aryl Hydrocarbon Receptor1wikipathways: Nuclear Receptors1wikipathways: miR-targeted genes in muscle cell - TarBase1wikipathways: Integrated Breast Cancer Pathway

Drug-gene GO enrichments

3MF: estrogen receptor activity3MF: RNA polymerase II transcription factor activity, sequence-specific DNA binding2BP: intracellular estrogen receptor signaling pathway2MF: RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding2BP: cellular response to estradiol stimulus1BP: regulation of intracellular estrogen receptor signaling pathway1BP: response to estradiol1BP: regulation of toll-like receptor signaling pathway1BP: regulation of apoptotic process1BP: negative regulation of I-kappaB kinase/NF-kappaB signaling

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
2099 ESR1 9
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Gene in drug-gene network: Network Plot

Models in GDC-0810

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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