iGMDRD757


Canonical SMILES: CC(C1=CN2C=CN=C2C=C1)N3C4=NC(=CN=C4N=N3)C5=CN(N=C5)C

InChI: InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1

InChI Key: XYDNMOZJKOGZLS-NSHDSACASA-N

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Standard Name
CHEMBL
Pubchem CID
DRUGBANK ID
Drug Status
Drug Type
Standard NameSavolitinib
Pubchem CID68289000
DRUGBANK IDDB12048
Drug StatusAlone
Drug TypeSmall Molecule

Drug-model tissue-cancer distribution: Bubble Plot

Drug-gene pathway enrichments

1reactome: mRNA Capping1reactome: Infectious disease1reactome: RNA Polymerase II Transcription1reactome: Gene expression (Transcription)1reactome: Metabolism of RNA1reactome: RNA Pol II CTD phosphorylation and interaction with CE1reactome: Transcription of the HIV genome1reactome: RNA Pol II CTD phosphorylation and interaction with CE during HIV infection1humancyc: mRNA capping1kegg: mRNA surveillance pathway - Homo sapiens (human)

Drug-gene GO enrichments

4BP: 7-methylguanosine mRNA capping4MF: mRNA (guanine-N7-)-methyltransferase activity2CC: nucleus2CC: nucleoplasm2CC: mRNA cap binding complex1CC: mRNA cap methyltransferase complex1CC: receptor complex1BP: cellular response to leukemia inhibitory factor1MF: protein binding1BP: transcription by RNA polymerase II

Drug-Gene: Aster Plot


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Gene ID
Gene Name
Model Num.
8731 RNMT 1
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Gene in drug-gene network: Network Plot

Models in Savolitinib

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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